Entity Details

Primary name SMAD4
Entity type gene
Source Source Link

Details

PrimaryID4089
RefseqGeneNG_013013
SymbolSMAD4
NameSMAD family member 4
Chromosome18
Location18q21.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-12
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsSMAD4_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001223 transcription coactivator binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001541 ovarian follicle development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0001702 gastrulation with mouth forming second
GO:0003148 outflow tract septum morphogenesis
GO:0003161 cardiac conduction system development
GO:0003190 atrioventricular valve formation
GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003220 left ventricular cardiac muscle tissue morphogenesis
GO:0003251 positive regulation of cell proliferation involved in heart valve morphogenesis
GO:0003360 brainstem development
GO:0003682 chromatin binding
GO:0005518 collagen binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0006879 cellular iron ion homeostasis
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007183 SMAD protein complex assembly
GO:0007283 spermatogenesis
GO:0007338 single fertilization
GO:0007411 axon guidance
GO:0008283 cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0009653 anatomical structure morphogenesis
GO:0010614 negative regulation of cardiac muscle hypertrophy
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0014033 neural crest cell differentiation
GO:0016579 protein deubiquitination
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0030154 cell differentiation
GO:0030308 negative regulation of cell growth
GO:0030509 BMP signaling pathway
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030513 positive regulation of BMP signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0032444 activin responsive factor complex
GO:0032525 somite rostral/caudal axis specification
GO:0032909 regulation of transforming growth factor beta2 production
GO:0033686 positive regulation of luteinizing hormone secretion
GO:0035019 somatic stem cell population maintenance
GO:0035556 intracellular signal transduction
GO:0036302 atrioventricular canal development
GO:0042118 endothelial cell activation
GO:0042733 embryonic digit morphogenesis
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043199 sulfate binding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0046881 positive regulation of follicle-stimulating hormone secretion
GO:0048382 mesendoderm development
GO:0048589 developmental growth
GO:0048663 neuron fate commitment
GO:0048733 sebaceous gland development
GO:0048859 formation of anatomical boundary
GO:0051098 regulation of binding
GO:0051571 positive regulation of histone H3-K4 methylation
GO:0051797 regulation of hair follicle development
GO:0060065 uterus development
GO:0060391 positive regulation of SMAD protein signal transduction
GO:0060395 SMAD protein signal transduction
GO:0060412 ventricular septum morphogenesis
GO:0060548 negative regulation of cell death
GO:0060956 endocardial cell differentiation
GO:0061040 female gonad morphogenesis
GO:0062009 secondary palate development
GO:0070102 interleukin-6-mediated signaling pathway
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070411 I-SMAD binding
GO:0070412 R-SMAD binding
GO:0071141 SMAD protein complex
GO:0071144 heteromeric SMAD protein complex
GO:0071559 response to transforming growth factor beta
GO:0071773 cellular response to BMP stimulus
GO:0072133 metanephric mesenchyme morphogenesis
GO:0072134 nephrogenic mesenchyme morphogenesis
GO:0072520 seminiferous tubule development
GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1905305 negative regulation of cardiac myofibril assembly
GO:2000617 positive regulation of histone H3-K9 acetylation

Diseases

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Interactions

51 interactions

InteractorPartnerSourcesPublicationsLink
SMAD4Usp9xIntAct19135894 details
SMAD4Zfp128BioGRID12370310 details
SMAD4Fbxo30MINT15761153 details
SMAD4Rhebl1MINT15761153 details
SMAD4Nat8MINT15761153 details
SMAD4Sash3MINT15761153 details
SMAD4Foxo1IntAct15084259 details
SMAD4HopxDIP26113728 details
SMAD4Dok1BioGRID11927552 details
SMAD4RhodBioGRID, MINT15761153 details
SMAD4Chek1BioGRID, MINT15761153 details
SMAD4Rab13BioGRID, MINT15761153 details
SMAD4Rab3bBioGRID, MINT15761153 details
SMAD4Plk4BioGRID, MINT15761153 details
SMAD4PbkBioGRID, MINT15761153 details
SMAD4Xpo1IntAct26673895 details
SMAD4RhogBioGRID15761153 details
SMAD4Rasd2BioGRID15761153 details
SMAD4RhojBioGRID15761153 details
SMAD4Rab2bBioGRID15761153 details
SMAD4Rac2BioGRID15761153 details
SMAD4Rab38BioGRID15761153 details
SMAD4Rras2BioGRID15761153 details
SMAD4Arfrp1BioGRID15761153 details
SMAD4Arl5bBioGRID15761153 details
SMAD4Arhgef7BioGRID15761153 details
SMAD4Sqstm1BioGRID15761153 details
SMAD4Nek6BioGRID15761153 details
SMAD4Stk35BioGRID15761153 details
SMAD4Ripk2BioGRID15761153 details
SMAD4Map2k3BioGRID15761153 details
SMAD4Eif2ak4BioGRID15761153 details
SMAD4Nuak2BioGRID15761153 details
SMAD4Tssk3BioGRID15761153 details
SMAD4Uhmk1BioGRID15761153 details
SMAD4IlkapBioGRID15761153 details
SMAD4Trim35BioGRID15761153 details
SMAD4Rnf14BioGRID15761153 details
SMAD4Rnf138BioGRID15761153 details
SMAD4Smad1BioGRID15761153 details
SMAD4Smad3BioGRID15761153 details
SMAD4OclnBioGRID15761153 details
SMAD4HdgfBioGRID15761153 details
SMAD4Rab34BioGRID15761153 details
SMAD4UbbBioGRID15761153 details
SMAD4Rps27aBioGRID15761153 details
SMAD4ItkBioGRID15761153 details
SMAD4Ap2b1BioGRID15761153 details
SMAD4Rsph14BioGRID15761153 details
SMAD4Smad2BioGRID15761153 details
SMAD4Apbb2BioGRID15761153 details