Entity Details

Primary name MCL1
Entity type gene
Source Source Link

Details

PrimaryID4170
RefseqGeneNG_029146
SymbolMCL1
NameMCL1 apoptosis regulator, BCL2 family member
Chromosome1
Location1q21.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1994-11-03
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsMCL1_HUMAN

GO terms

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GOName
GO:0001709 cell fate determination
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0007275 multicellular organism development
GO:0008320 protein transmembrane transporter activity
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010507 negative regulation of autophagy
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0019725 cellular homeostasis
GO:0034097 response to cytokine
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0046982 protein heterodimerization activity
GO:0051434 BH3 domain binding
GO:0097136 Bcl-2 family protein complex
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:2000811 negative regulation of anoikis
GO:2001020 regulation of response to DNA damage stimulus
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway

Diseases

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Interactions

6 interactions