Entity Details

Primary name MDM2
Entity type gene
Source Source Link

Details

PrimaryID4193
RefseqGeneNG_016708
SymbolMDM2
NameMDM2 proto-oncogene
Chromosome12
Location12q15
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1994-12-22
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsMDM2_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000209 protein polyubiquitination
GO:0002039 p53 binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006915 apoptotic process
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0008097 5S rRNA binding
GO:0008270 zinc ion binding
GO:0008284 positive regulation of cell population proliferation
GO:0016032 viral process
GO:0016567 protein ubiquitination
GO:0016579 protein deubiquitination
GO:0016874 ligase activity
GO:0019789 SUMO transferase activity
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0030666 endocytic vesicle membrane
GO:0031625 ubiquitin protein ligase binding
GO:0031648 protein destabilization
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032991 protein-containing complex
GO:0034504 protein localization to nucleus
GO:0036369 transcription factor catabolic process
GO:0042176 regulation of protein catabolic process
GO:0042802 identical protein binding
GO:0043021 ribonucleoprotein complex binding
GO:0043130 ubiquitin binding
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045184 establishment of protein localization
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045931 positive regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046677 response to antibiotic
GO:0047485 protein N-terminus binding
GO:0051603 proteolysis involved in cellular protein catabolic process
GO:0051865 protein autoubiquitination
GO:0061630 ubiquitin protein ligase activity
GO:0061663 NEDD8 ligase activity
GO:0065003 protein-containing complex assembly
GO:0071456 cellular response to hypoxia
GO:0071480 cellular response to gamma radiation
GO:0072717 cellular response to actinomycin D
GO:0097718 disordered domain specific binding
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1901797 negative regulation of signal transduction by p53 class mediator
GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:1990000 amyloid fibril formation

Diseases

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