Entity Details

Primary name MRE11
Entity type gene
Source Source Link

Details

PrimaryID4361
RefseqGeneNG_007261
SymbolMRE11
NameMRE11 homolog, double strand break repair nuclease
Chromosome11
Location11q21
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1997-10-10
ModificationDate2021-06-13

Ontological Relatives

UniProt IDsMRE11_HUMAN

GO terms

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GOName
GO:0000014 single-stranded DNA endodeoxyribonuclease activity
GO:0000019 regulation of mitotic recombination
GO:0000723 telomere maintenance
GO:0000724 double-strand break repair via homologous recombination
GO:0000729 DNA double-strand break processing
GO:0000781 chromosome, telomeric region
GO:0003690 double-stranded DNA binding
GO:0004518 nuclease activity
GO:0004520 endodeoxyribonuclease activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005657 replication fork
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006310 DNA recombination
GO:0006974 cellular response to DNA damage stimulus
GO:0007004 telomere maintenance via telomerase
GO:0007062 sister chromatid cohesion
GO:0007095 mitotic G2 DNA damage checkpoint signaling
GO:0007129 homologous chromosome pairing at meiosis
GO:0007131 reciprocal meiotic recombination
GO:0008022 protein C-terminus binding
GO:0008283 cell population proliferation
GO:0008296 3'-5'-exodeoxyribonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0008409 5'-3' exonuclease activity
GO:0016032 viral process
GO:0016605 PML body
GO:0030145 manganese ion binding
GO:0030870 Mre11 complex
GO:0031573 mitotic intra-S DNA damage checkpoint signaling
GO:0031860 telomeric 3' overhang formation
GO:0031954 positive regulation of protein autophosphorylation
GO:0032206 positive regulation of telomere maintenance
GO:0032481 positive regulation of type I interferon production
GO:0032508 DNA duplex unwinding
GO:0033674 positive regulation of kinase activity
GO:0035861 site of double-strand break
GO:0042138 meiotic DNA double-strand break formation
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0045296 cadherin binding
GO:0097552 mitochondrial double-strand break repair via homologous recombination
GO:0110025 DNA strand resection involved in replication fork processing
GO:1901796 regulation of signal transduction by p53 class mediator

Diseases

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Interactions

5 interactions