Entity Details

Primary name MSH2
Entity type gene
Source Source Link

Details

PrimaryID4436
RefseqGeneNG_007110
SymbolMSH2
NamemutS homolog 2
Chromosome2
Location2p21-p16.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-20
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsMSH2_HUMAN

GO terms

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GOName
GO:0000406 double-strand/single-strand DNA junction binding
GO:0000781 chromosome, telomeric region
GO:0001701 in utero embryonic development
GO:0002204 somatic recombination of immunoglobulin genes involved in immune response
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003684 damaged DNA binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006119 oxidative phosphorylation
GO:0006281 DNA repair
GO:0006298 mismatch repair
GO:0006301 postreplication repair
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0007281 germ cell development
GO:0008022 protein C-terminus binding
GO:0008094 ATPase, acting on DNA
GO:0008340 determination of adult lifespan
GO:0008584 male gonad development
GO:0010165 response to X-ray
GO:0010224 response to UV-B
GO:0016020 membrane
GO:0016446 somatic hypermutation of immunoglobulin genes
GO:0016447 somatic recombination of immunoglobulin gene segments
GO:0019237 centromeric DNA binding
GO:0019724 B cell mediated immunity
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0030183 B cell differentiation
GO:0031573 mitotic intra-S DNA damage checkpoint signaling
GO:0032137 guanine/thymine mispair binding
GO:0032300 mismatch repair complex
GO:0032301 MutSalpha complex
GO:0032302 MutSbeta complex
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042803 protein homodimerization activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0043570 maintenance of DNA repeat elements
GO:0045190 isotype switching
GO:0045910 negative regulation of DNA recombination
GO:0048298 positive regulation of isotype switching to IgA isotypes
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0051096 positive regulation of helicase activity
GO:0071168 protein localization to chromatin

Diseases

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Interactions

5 interactions

InteractorPartnerSourcesPublicationsLink
MSH2AireIntAct20085707 details
MSH2PcnaBioGRID, IntAct26496610 details
MSH2JmyUniProt25015719 details
MSH2Prdm16MINT30462309 details
MSH2MecomMINT30462309 details