Entity Details

Primary name MTHFD1
Entity type gene
Source Source Link

Details

PrimaryID4522
RefseqGeneNG_012450
SymbolMTHFD1
Namemethylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
Chromosome14
Location14q23.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-07-23
ModificationDate2021-06-19

Ontological Relatives

UniProt IDsC1TC_HUMAN

GO terms

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GOName
GO:0000105 histidine biosynthetic process
GO:0001843 neural tube closure
GO:0004329 formate-tetrahydrofolate ligase activity
GO:0004477 methenyltetrahydrofolate cyclohydrolase activity
GO:0004486 methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity
GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity
GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005524 ATP binding
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006164 purine nucleotide biosynthetic process
GO:0006555 methionine metabolic process
GO:0006730 one-carbon metabolic process
GO:0007507 heart development
GO:0009069 serine family amino acid metabolic process
GO:0009070 serine family amino acid biosynthetic process
GO:0009086 methionine biosynthetic process
GO:0009257 10-formyltetrahydrofolate biosynthetic process
GO:0016020 membrane
GO:0035999 tetrahydrofolate interconversion
GO:0046655 folic acid metabolic process
GO:0048702 embryonic neurocranium morphogenesis
GO:0048703 embryonic viscerocranium morphogenesis
GO:0061053 somite development
GO:0070062 extracellular exosome

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
MTHFD1Cbx4BioGRID, IntAct26496610 details
MTHFD1Prdm16MINT30462309 details