Entity Details

Primary name PDK4_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionO70571
EntryNamePDK4_MOUSE
FullName[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial
TaxID10090
Evidenceevidence at protein level
Length412
SequenceStatuscomplete
DateCreated2001-01-24
DateModified2021-06-02

Ontological Relatives

GenesPdk4

GO terms

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GOName
GO:0004672 protein kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005524 ATP binding
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0006006 glucose metabolic process
GO:0006468 protein phosphorylation
GO:0006885 regulation of pH
GO:0008286 insulin receptor signaling pathway
GO:0009267 cellular response to starvation
GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0010565 regulation of cellular ketone metabolic process
GO:0010906 regulation of glucose metabolic process
GO:0042304 regulation of fatty acid biosynthetic process
GO:0042593 glucose homeostasis
GO:0042594 response to starvation
GO:0045124 regulation of bone resorption
GO:0046320 regulation of fatty acid oxidation
GO:0071398 cellular response to fatty acid
GO:0072593 reactive oxygen species metabolic process
GO:2000811 negative regulation of anoikis

Subcellular Location

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Subcellular Location
Mitochondrion matrix

Domains

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DomainNameCategoryType
IPR003594 Histidine kinase/HSP90-like ATPaseDomainDomain
IPR005467 Histidine kinase domainDomainDomain
IPR018955 Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminalDomainDomain
IPR036784 Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamilyFamilyHomologous superfamily
IPR036890 Histidine kinase/HSP90-like ATPase superfamilyFamilyHomologous superfamily
IPR039028 PDK/BCKDK protein kinaseFamilyFamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
PDK4_MOUSECREB1_MOUSEBioGRID25164809 details