Entity Details

Primary name NOTCH2
Entity type gene
Source Source Link

Details

PrimaryID4853
RefseqGeneNG_008163
SymbolNOTCH2
Namenotch receptor 2
Chromosome1
Location1p12
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1995-01-30
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsNOTC2_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000139 Golgi membrane
GO:0001701 in utero embryonic development
GO:0001709 cell fate determination
GO:0001947 heart looping
GO:0002011 morphogenesis of an epithelial sheet
GO:0002315 marginal zone B cell differentiation
GO:0002437 inflammatory response to antigenic stimulus
GO:0003162 atrioventricular node development
GO:0003184 pulmonary valve morphogenesis
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005929 cilium
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006915 apoptotic process
GO:0006959 humoral immune response
GO:0007219 Notch signaling pathway
GO:0007275 multicellular organism development
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0009887 animal organ morphogenesis
GO:0009986 cell surface
GO:0010629 negative regulation of gene expression
GO:0010838 positive regulation of keratinocyte proliferation
GO:0016020 membrane
GO:0019827 stem cell population maintenance
GO:0019899 enzyme binding
GO:0030097 hemopoiesis
GO:0030326 embryonic limb morphogenesis
GO:0030513 positive regulation of BMP signaling pathway
GO:0035264 multicellular organism growth
GO:0035622 intrahepatic bile duct development
GO:0038023 signaling receptor activity
GO:0042060 wound healing
GO:0042742 defense response to bacterium
GO:0043011 myeloid dendritic cell differentiation
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043235 receptor complex
GO:0045672 positive regulation of osteoclast differentiation
GO:0045967 negative regulation of growth rate
GO:0046579 positive regulation of Ras protein signal transduction
GO:0046849 bone remodeling
GO:0051059 NF-kappaB binding
GO:0060413 atrial septum morphogenesis
GO:0060674 placenta blood vessel development
GO:0061073 ciliary body morphogenesis
GO:0061314 Notch signaling involved in heart development
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070986 left/right axis specification
GO:0072014 proximal tubule development
GO:0072015 glomerular visceral epithelial cell development
GO:0072104 glomerular capillary formation
GO:0072574 hepatocyte proliferation
GO:1990705 cholangiocyte proliferation
GO:2000249 regulation of actin cytoskeleton reorganization
GO:2001204 regulation of osteoclast development

Diseases

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Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
NOTCH2Lats2IntAct24255178 details
NOTCH2Bmpr1aBioGRID, IntAct26496610 details
NOTCH2Rnf183BioGRID31732153 details