Entity Details

Primary name APH1A
Entity type gene
Source Source Link

Details

PrimaryID51107
RefseqGeneNG_029952
SymbolAPH1A
Nameaph-1 homolog A, gamma-secretase subunit
Chromosome1
Location1q21.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-05-11
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsAPH1A_HUMAN

GO terms

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GOName
GO:0001656 metanephros development
GO:0005739 mitochondrion
GO:0005769 early endosome
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006509 membrane protein ectodomain proteolysis
GO:0007219 Notch signaling pathway
GO:0007220 Notch receptor processing
GO:0008021 synaptic vesicle
GO:0010008 endosome membrane
GO:0010950 positive regulation of endopeptidase activity
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016485 protein processing
GO:0019899 enzyme binding
GO:0030674 protein-macromolecule adaptor activity
GO:0031293 membrane protein intracellular domain proteolysis
GO:0032580 Golgi cisterna membrane
GO:0034205 amyloid-beta formation
GO:0035333 Notch receptor processing, ligand-dependent
GO:0042982 amyloid precursor protein metabolic process
GO:0042987 amyloid precursor protein catabolic process
GO:0043065 positive regulation of apoptotic process
GO:0043085 positive regulation of catalytic activity
GO:0048013 ephrin receptor signaling pathway
GO:0061133 endopeptidase activator activity
GO:0070765 gamma-secretase complex
GO:0099056 integral component of presynaptic membrane
GO:1990000 amyloid fibril formation

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
APH1APsen2BioGRID, MINT19376115 details