Entity Details

Primary name PDE4D
Entity type gene
Source Source Link

Details

PrimaryID5144
RefseqGeneNG_027957
SymbolPDE4D
Namephosphodiesterase 4D
Chromosome5
Location5q11.2-q12.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1994-07-29
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsPDE4D_HUMAN

GO terms

Show/Hide Table
GOName
GO:0002027 regulation of heart rate
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
GO:0005634 nucleus
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0006198 cAMP catabolic process
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0010469 regulation of signaling receptor activity
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0019899 enzyme binding
GO:0019933 cAMP-mediated signaling
GO:0030552 cAMP binding
GO:0031698 beta-2 adrenergic receptor binding
GO:0032729 positive regulation of interferon-gamma production
GO:0032743 positive regulation of interleukin-2 production
GO:0032754 positive regulation of interleukin-5 production
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0034704 calcium channel complex
GO:0043951 negative regulation of cAMP-mediated signaling
GO:0044325 transmembrane transporter binding
GO:0045822 negative regulation of heart contraction
GO:0046872 metal ion binding
GO:0048471 perinuclear region of cytoplasm
GO:0050852 T cell receptor signaling pathway
GO:0051117 ATPase binding
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity
GO:0061028 establishment of endothelial barrier
GO:0071320 cellular response to cAMP
GO:0071872 cellular response to epinephrine stimulus
GO:0071875 adrenergic receptor signaling pathway
GO:0086004 regulation of cardiac muscle cell contraction
GO:0086024 adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate
GO:0097110 scaffold protein binding
GO:1901363 heterocyclic compound binding
GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction
GO:1901898 negative regulation of relaxation of cardiac muscle

Diseases

Show/Hide Table

Interactions

6 interactions

InteractorPartnerSourcesPublicationsLink
PDE4DBub1BioGRID, IntAct20360068 26496610 details
PDE4DCep152BioGRID, IntAct26496610 details
PDE4DSmap1BioGRID, IntAct26496610 details
PDE4DPdlim5BioGRID, IntAct26496610 details
PDE4DSmoBioGRID, IntAct26496610 details
PDE4DPtpn13BioGRID26496610 details