Entity Details

Primary name SIRT6
Entity type gene
Source Source Link

Details

PrimaryID51548
RefseqGeneNG_047153
SymbolSIRT6
Namesirtuin 6
Chromosome19
Location19p13.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2001-03-22
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsSIR6_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0003247 post-embryonic cardiac muscle cell growth involved in heart morphogenesis
GO:0003714 transcription corepressor activity
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity
GO:0004407 histone deacetylase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006471 protein ADP-ribosylation
GO:0006476 protein deacetylation
GO:0008270 zinc ion binding
GO:0010569 regulation of double-strand break repair via homologous recombination
GO:0017136 NAD-dependent histone deacetylase activity
GO:0019213 deacetylase activity
GO:0031667 response to nutrient levels
GO:0031940 positive regulation of chromatin silencing at telomere
GO:0032206 positive regulation of telomere maintenance
GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0070403 NAD+ binding
GO:0070932 histone H3 deacetylation
GO:0099115 chromosome, subtelomeric region
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1901485 positive regulation of transcription factor catabolic process
GO:1902732 positive regulation of chondrocyte proliferation
GO:1905549 positive regulation of subtelomeric heterochromatin assembly
GO:1905555 positive regulation of blood vessel branching
GO:1905564 positive regulation of vascular endothelial cell proliferation

Diseases

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Interactions

5 interactions

InteractorPartnerSourcesPublicationsLink
SIRT6Ddb1BioGRID26496610 details
SIRT6Rock1BioGRID26496610 details
SIRT6Cdc26BioGRID26496610 details
SIRT6Kctd5BioGRID26496610 details
SIRT6Vangl1BioGRID26496610 details