Entity Details

Primary name WWP2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ9DBH0
EntryNameWWP2_MOUSE
FullNameNEDD4-like E3 ubiquitin-protein ligase WWP2
TaxID10090
Evidenceevidence at protein level
Length870
SequenceStatuscomplete
DateCreated2003-06-20
DateModified2021-06-02

Ontological Relatives

GenesWwp2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000209 protein polyubiquitination
GO:0004842 ubiquitin-protein transferase activity
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0006858 extracellular transport
GO:0008134 transcription factor binding
GO:0010629 negative regulation of gene expression
GO:0016567 protein ubiquitination
GO:0032410 negative regulation of transporter activity
GO:0034765 regulation of ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0045732 positive regulation of protein catabolic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051224 negative regulation of protein transport
GO:0051865 protein autoubiquitination
GO:0061630 ubiquitin protein ligase activity
GO:0070534 protein K63-linked ubiquitination
GO:1901016 regulation of potassium ion transmembrane transporter activity

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000569 HECT domainDomainDomain
IPR001202 WW domainDomainDomain
IPR024928 E3 ubiquitin-protein ligase, SMURF1 typeFamilyFamily
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR035983 HECT, E3 ligase catalytic domainFamilyHomologous superfamily
IPR036020 WW domain superfamilyFamilyHomologous superfamily

Diseases

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