Entity Details

Primary name PFN1
Entity type gene
Source Source Link

Details

PrimaryID5216
RefseqGeneNG_012063
SymbolPFN1
Nameprofilin 1
Chromosome17
Location17p13.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-27
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsPROF1_HUMAN

GO terms

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GOName
GO:0000774 adenyl-nucleotide exchange factor activity
GO:0001784 phosphotyrosine residue binding
GO:0003723 RNA binding
GO:0003779 actin binding
GO:0003785 actin monomer binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0010634 positive regulation of epithelial cell migration
GO:0016020 membrane
GO:0030036 actin cytoskeleton organization
GO:0030833 regulation of actin filament polymerization
GO:0030837 negative regulation of actin filament polymerization
GO:0030838 positive regulation of actin filament polymerization
GO:0032232 negative regulation of actin filament bundle assembly
GO:0032233 positive regulation of actin filament bundle assembly
GO:0032781 positive regulation of ATPase activity
GO:0045296 cadherin binding
GO:0050821 protein stabilization
GO:0051497 negative regulation of stress fiber assembly
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0070062 extracellular exosome
GO:0070064 proline-rich region binding
GO:0072562 blood microparticle
GO:1900029 positive regulation of ruffle assembly

Diseases

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Interactions

9 interactions

InteractorPartnerSourcesPublicationsLink
PFN1Diaph1mbinfo9214622 details
PFN1Mapk13BioGRID19135240 details
PFN1Csnk1eBioGRID, IntAct20360068 details
PFN1Akap12BioGRID, IntAct20360068 details
PFN1AI837181BioGRID, IntAct20360068 details
PFN1Flot1BioGRID, IntAct26496610 details
PFN1ActbBioGRID, IntAct26496610 details
PFN1Mast3BioGRID, IntAct26496610 details
PFN1Rnf183BioGRID31732153 details