Entity Details

Primary name PHB
Entity type gene
Source Source Link

Details

PrimaryID5245
RefseqGeneNG_023046
SymbolPHB
Nameprohibitin
Chromosome17
Location17q21.33
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1991-07-08
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsPHB_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001541 ovarian follicle development
GO:0001552 ovarian follicle atresia
GO:0001649 osteoblast differentiation
GO:0001850 complement component C3a binding
GO:0001851 complement component C3b binding
GO:0002639 positive regulation of immunoglobulin production
GO:0003714 transcription corepressor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006355 regulation of transcription, DNA-templated
GO:0006851 mitochondrial calcium ion transmembrane transport
GO:0007005 mitochondrion organization
GO:0007165 signal transduction
GO:0007202 activation of phospholipase C activity
GO:0008022 protein C-terminus binding
GO:0008285 negative regulation of cell population proliferation
GO:0009986 cell surface
GO:0010628 positive regulation of gene expression
GO:0010942 positive regulation of cell death
GO:0010944 negative regulation of transcription by competitive promoter binding
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016575 histone deacetylation
GO:0019899 enzyme binding
GO:0023035 CD40 signaling pathway
GO:0030061 mitochondrial crista
GO:0030308 negative regulation of cell growth
GO:0031100 animal organ regeneration
GO:0031315 extrinsic component of mitochondrial outer membrane
GO:0031871 proteinase activated receptor binding
GO:0032740 positive regulation of interleukin-17 production
GO:0035632 mitochondrial prohibitin complex
GO:0035902 response to immobilization stress
GO:0039529 RIG-I signaling pathway
GO:0042113 B cell activation
GO:0042177 negative regulation of protein catabolic process
GO:0042493 response to drug
GO:0042826 histone deacetylase binding
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043434 response to peptide hormone
GO:0044830 modulation by host of viral RNA genome replication
GO:0045471 response to ethanol
GO:0045745 positive regulation of G protein-coupled receptor signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045917 positive regulation of complement activation
GO:0046718 viral entry into host cell
GO:0046982 protein heterodimerization activity
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050821 protein stabilization
GO:0050847 progesterone receptor signaling pathway
GO:0051897 positive regulation of protein kinase B signaling
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:0070062 extracellular exosome
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071354 cellular response to interleukin-6
GO:0071897 DNA biosynthetic process
GO:0072538 T-helper 17 type immune response
GO:0098891 extrinsic component of presynaptic active zone membrane
GO:0098978 glutamatergic synapse
GO:0098982 GABA-ergic synapse
GO:0140374 antiviral innate immune response
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1990051 activation of protein kinase C activity
GO:2000323 negative regulation of glucocorticoid receptor signaling pathway

Diseases

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Interactions

17 interactions

InteractorPartnerSourcesPublicationsLink
PHBTnfrsf19MINT30337686 details
PHBAI837181BioGRID, IntAct20360068 details
PHBBmpr1aBioGRID, IntAct26496610 details
PHBRab5cBioGRID, IntAct26496610 details
PHBRmdn3BioGRID, IntAct26496610 details
PHBRab11aBioGRID, IntAct26496610 details
PHBEef1a1BioGRID, IntAct26496610 details
PHBLima1BioGRID, IntAct26496610 details
PHBTmem109BioGRID, IntAct26496610 details
PHBAtp2a2BioGRID, IntAct26496610 details
PHBAifm1BioGRID, IntAct26496610 details
PHBMtx2BioGRID, IntAct26496610 details
PHBTmed2BioGRID, IntAct26496610 details
PHBPrdm16MINT30462309 details
PHBMecomMINT30462309 details
PHBDppa3BioGRID28712289 details
PHBRnf183BioGRID31732153 details