Entity Details

Primary name PRNP
Entity type gene
Source Source Link

Details

PrimaryID5621
RefseqGeneNG_009087
SymbolPRNP
Nameprion protein
Chromosome20
Location20p13
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1994-01-07
ModificationDate2021-06-22

Ontological Relatives

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0001933 negative regulation of protein phosphorylation
GO:0002020 protease binding
GO:0005507 copper ion binding
GO:0005509 calcium ion binding
GO:0005539 glycosaminoglycan binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006878 cellular copper ion homeostasis
GO:0006979 response to oxidative stress
GO:0007611 learning or memory
GO:0007616 long-term memory
GO:0008017 microtubule binding
GO:0009986 cell surface
GO:0010955 negative regulation of protein processing
GO:0014069 postsynaptic density
GO:0015631 tubulin binding
GO:0016021 integral component of membrane
GO:0016234 inclusion body
GO:0019828 aspartic-type endopeptidase inhibitor activity
GO:0019898 extrinsic component of membrane
GO:0031362 anchored component of external side of plasma membrane
GO:0031648 protein destabilization
GO:0031802 type 5 metabotropic glutamate receptor binding
GO:0031965 nuclear membrane
GO:0032689 negative regulation of interferon-gamma production
GO:0032700 negative regulation of interleukin-17 production
GO:0032703 negative regulation of interleukin-2 production
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0038023 signaling receptor activity
GO:0042802 identical protein binding
GO:0043231 intracellular membrane-bounded organelle
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043525 positive regulation of neuron apoptotic process
GO:0044877 protein-containing complex binding
GO:0045048 protein insertion into ER membrane
GO:0045121 membrane raft
GO:0046007 negative regulation of activated T cell proliferation
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0051260 protein homooligomerization
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0070062 extracellular exosome
GO:0070885 negative regulation of calcineurin-NFAT signaling cascade
GO:0071280 cellular response to copper ion
GO:0090314 positive regulation of protein targeting to membrane
GO:0090647 modulation of age-related behavioral decline
GO:0097062 dendritic spine maintenance
GO:0098794 postsynapse
GO:1900449 regulation of glutamate receptor signaling pathway
GO:1901216 positive regulation of neuron death
GO:1902430 negative regulation of amyloid-beta formation
GO:1902938 regulation of intracellular calcium activated chloride channel activity
GO:1902951 negative regulation of dendritic spine maintenance
GO:1902992 negative regulation of amyloid precursor protein catabolic process
GO:1903136 cuprous ion binding
GO:1904645 response to amyloid-beta
GO:1904646 cellular response to amyloid-beta
GO:1905664 regulation of calcium ion import across plasma membrane
GO:1990535 neuron projection maintenance

Diseases

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Interactions

7 interactions