Entity Details

Primary name PTEN
Entity type gene
Source Source Link

Details

PrimaryID5728
RefseqGeneNG_007466
SymbolPTEN
Namephosphatase and tensin homolog
Chromosome10
Location10q23.31
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-19
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsPTEN_HUMAN

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001933 negative regulation of protein phosphorylation
GO:0002902 regulation of B cell apoptotic process
GO:0004438 phosphatidylinositol-3-phosphatase activity
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005161 platelet-derived growth factor receptor binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006470 protein dephosphorylation
GO:0006661 phosphatidylinositol biosynthetic process
GO:0006915 apoptotic process
GO:0007270 neuron-neuron synaptic transmission
GO:0007416 synapse assembly
GO:0007417 central nervous system development
GO:0007507 heart development
GO:0007568 aging
GO:0007584 response to nutrient
GO:0007611 learning or memory
GO:0007613 memory
GO:0007626 locomotory behavior
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0008289 lipid binding
GO:0009749 response to glucose
GO:0009898 cytoplasmic side of plasma membrane
GO:0010043 response to zinc ion
GO:0010628 positive regulation of gene expression
GO:0010666 positive regulation of cardiac muscle cell apoptotic process
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0010975 regulation of neuron projection development
GO:0010977 negative regulation of neuron projection development
GO:0010997 anaphase-promoting complex binding
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling
GO:0014823 response to activity
GO:0016311 dephosphorylation
GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0016324 apical plasma membrane
GO:0016477 cell migration
GO:0016579 protein deubiquitination
GO:0016605 PML body
GO:0019899 enzyme binding
GO:0021542 dentate gyrus development
GO:0021955 central nervous system neuron axonogenesis
GO:0030165 PDZ domain binding
GO:0030336 negative regulation of cell migration
GO:0030534 adult behavior
GO:0031642 negative regulation of myelination
GO:0031647 regulation of protein stability
GO:0032228 regulation of synaptic transmission, GABAergic
GO:0032286 central nervous system myelin maintenance
GO:0032355 response to estradiol
GO:0032535 regulation of cellular component size
GO:0032869 cellular response to insulin stimulus
GO:0033032 regulation of myeloid cell apoptotic process
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0033198 response to ATP
GO:0033555 multicellular organismal response to stress
GO:0035176 social behavior
GO:0035255 ionotropic glutamate receptor binding
GO:0035749 myelin sheath adaxonal region
GO:0042493 response to drug
GO:0042711 maternal behavior
GO:0042802 identical protein binding
GO:0042995 cell projection
GO:0043005 neuron projection
GO:0043066 negative regulation of apoptotic process
GO:0043197 dendritic spine
GO:0043220 Schmidt-Lanterman incisure
GO:0043491 protein kinase B signaling
GO:0043542 endothelial cell migration
GO:0043647 inositol phosphate metabolic process
GO:0044320 cellular response to leptin stimulus
GO:0045211 postsynaptic membrane
GO:0045475 locomotor rhythm
GO:0045666 positive regulation of neuron differentiation
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045792 negative regulation of cell size
GO:0046621 negative regulation of organ growth
GO:0046685 response to arsenic-containing substance
GO:0046855 inositol phosphate dephosphorylation
GO:0046856 phosphatidylinositol dephosphorylation
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048681 negative regulation of axon regeneration
GO:0048738 cardiac muscle tissue development
GO:0048853 forebrain morphogenesis
GO:0048854 brain morphogenesis
GO:0048870 cell motility
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050765 negative regulation of phagocytosis
GO:0050771 negative regulation of axonogenesis
GO:0050821 protein stabilization
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051548 negative regulation of keratinocyte migration
GO:0051717 inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
GO:0051895 negative regulation of focal adhesion assembly
GO:0051896 regulation of protein kinase B signaling
GO:0051898 negative regulation of protein kinase B signaling
GO:0060024 rhythmic synaptic transmission
GO:0060044 negative regulation of cardiac muscle cell proliferation
GO:0060070 canonical Wnt signaling pathway
GO:0060074 synapse maturation
GO:0060134 prepulse inhibition
GO:0060179 male mating behavior
GO:0060260 regulation of transcription initiation from RNA polymerase II promoter
GO:0060291 long-term synaptic potentiation
GO:0060292 long-term synaptic depression
GO:0060736 prostate gland growth
GO:0060997 dendritic spine morphogenesis
GO:0061002 negative regulation of dendritic spine morphogenesis
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071257 cellular response to electrical stimulus
GO:0071361 cellular response to ethanol
GO:0071456 cellular response to hypoxia
GO:0090071 negative regulation of ribosome biogenesis
GO:0090344 negative regulation of cell aging
GO:0090394 negative regulation of excitatory postsynaptic potential
GO:0097105 presynaptic membrane assembly
GO:0097107 postsynaptic density assembly
GO:0099524 postsynaptic cytosol
GO:0106306 protein serine phosphatase activity
GO:0106307 protein threonine phosphatase activity
GO:1901017 negative regulation of potassium ion transmembrane transporter activity
GO:1902807 negative regulation of cell cycle G1/S phase transition
GO:1903690 negative regulation of wound healing, spreading of epidermal cells
GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway
GO:1904668 positive regulation of ubiquitin protein ligase activity
GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation
GO:1990090 cellular response to nerve growth factor stimulus
GO:1990314 cellular response to insulin-like growth factor stimulus
GO:1990381 ubiquitin-specific protease binding
GO:1990782 protein tyrosine kinase binding
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
GO:2000272 negative regulation of signaling receptor activity
GO:2000463 positive regulation of excitatory postsynaptic potential
GO:2000808 negative regulation of synaptic vesicle clustering

Diseases

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Interactions

110 interactions

InteractorPartnerSourcesPublicationsLink
PTENMast2IntAct15951562 details
PTENMast1IntAct15951562 details
PTENSlc9a3r2BioGRID, MINT16456542 details
PTENCenpc1IntAct17218262 details
PTENPtenIntAct17218262 details
PTENSmurf2BioGRID, IntAct19379695 details
PTENNedd4BioGRID18307411 details
PTENCtpsBioGRID18307411 details
PTENPuf60BioGRID18307411 details
PTENIdh1BioGRID18307411 details
PTENHnrnpuBioGRID18307411 details
PTENPcbp2BioGRID18307411 details
PTENHnrnpfBioGRID18307411 details
PTENPcbp1BioGRID18307411 details
PTENPsmc3BioGRID18307411 details
PTENEef1b2BioGRID18307411 details
PTENHnrnpa2b1BioGRID18307411 details
PTENCct3BioGRID18307411 details
PTENAcat2BioGRID18307411 details
PTENTcp1BioGRID18307411 details
PTENAnxa1BioGRID18307411 details
PTENNclBioGRID18307411 details
PTENVcpBioGRID18307411 details
PTENSerpinh1BioGRID18307411 details
PTENAkr1b3BioGRID18307411 details
PTENCfl1BioGRID18307411 details
PTENRplp0BioGRID18307411 details
PTENCltcBioGRID18307411 details
PTENRps7BioGRID18307411 details
PTENCct7BioGRID18307411 details
PTENHsp90ab1BioGRID18307411 details
PTENEef1dBioGRID18307411 details
PTENAclyBioGRID18307411 details
PTENAtp5a1BioGRID18307411 details
PTENCct6aBioGRID18307411 details
PTENEsdBioGRID18307411 details
PTENAldh1a1BioGRID18307411 details
PTENHnrnpkBioGRID18307411 details
PTENOxct1BioGRID18307411 details
PTENLdhaBioGRID18307411 details
PTENTubb5BioGRID18307411 details
PTENUgdhBioGRID18307411 details
PTENCct5BioGRID18307411 details
PTENMap1bBioGRID18307411 details
PTENEef1gBioGRID18307411 details
PTENActa1BioGRID18307411 details
PTENPfn1BioGRID18307411 details
PTENHspa8BioGRID18307411 details
PTENActr1aBioGRID18307411 details
PTENEef2BioGRID18307411 details
PTENMtapBioGRID18307411 details
PTENTubb6BioGRID18307411 details
PTENSnd1BioGRID18307411 details
PTENPcnaBioGRID18307411 details
PTENCct4BioGRID18307411 details
PTENRack1BioGRID18307411 details
PTENHspa5BioGRID18307411 details
PTENPkmBioGRID18307411 details
PTENRps3BioGRID18307411 details
PTENNap1l1BioGRID18307411 details
PTENAldh1a7BioGRID18307411 details
PTENHnrnplBioGRID18307411 details
PTENHsp90b1BioGRID18307411 details
PTENFasnBioGRID18307411 details
PTENEef1a1BioGRID18307411 details
PTENActbBioGRID18307411 details
PTENPgk1BioGRID18307411 details
PTENEif4a1BioGRID18307411 details
PTENTuba1bBioGRID18307411 details
PTENEno1BioGRID18307411 details
PTENHspd1BioGRID18307411 details
PTENNpm1BioGRID18307411 details
PTENPpiaBioGRID18307411 details
PTENGdi2BioGRID18307411 details
PTENHsp90aa1BioGRID18307411 details
PTENTubb4bBioGRID18307411 details
PTENPsmc2BioGRID18307411 details
PTENRps4xBioGRID18307411 details
PTENArcn1BioGRID18307411 details
PTENSnrpd1BioGRID18307411 details
PTENHnrnpa3BioGRID18307411 details
PTENTubb2bBioGRID18307411 details
PTENAarsBioGRID18307411 details
PTENNarsBioGRID18307411 details
PTENRpl23BioGRID18307411 details
PTENTpi1BioGRID18307411 details
PTENLgals1BioGRID18307411 details
PTENSlc25a3BioGRID18307411 details
PTENAcat1BioGRID18307411 details
PTENPsmd12BioGRID18307411 details
PTENRpl22l1BioGRID18307411 details
PTENUba1BioGRID18307411 details
PTENMyh9BioGRID18307411 details
PTENRps17BioGRID18307411 details
PTENCap1BioGRID18307411 details
PTENDdx3xBioGRID18307411 details
PTENRpl18BioGRID18307411 details
PTENSlc25a4BioGRID18307411 details
PTENRpl3BioGRID18307411 details
PTENCfl2BioGRID18307411 details
PTENSrmBioGRID18307411 details
PTENRplp1BioGRID18307411 details
PTENActr3BioGRID18307411 details
PTENPsmc4BioGRID18307411 details
PTENLoxBioGRID18307411 details
PTENCapn2BioGRID18307411 details
PTENDstnBioGRID18307411 details
PTENRpl11BioGRID18307411 details
PTENFusBioGRID18307411 details
PTENFlnaBioGRID18307411 details