Entity Details

Primary name PTGS2
Entity type gene
Source Source Link

Details

PrimaryID5743
RefseqGeneNG_028206
SymbolPTGS2
Nameprostaglandin-endoperoxide synthase 2
Chromosome1
Location1q31.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-19
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsPGH2_HUMAN

GO terms

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GOName
GO:0001516 prostaglandin biosynthetic process
GO:0004601 peroxidase activity
GO:0004666 prostaglandin-endoperoxide synthase activity
GO:0005637 nuclear inner membrane
GO:0005640 nuclear outer membrane
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005789 endoplasmic reticulum membrane
GO:0006954 inflammatory response
GO:0006979 response to oxidative stress
GO:0008217 regulation of blood pressure
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0019221 cytokine-mediated signaling pathway
GO:0019371 cyclooxygenase pathway
GO:0019372 lipoxygenase pathway
GO:0019899 enzyme binding
GO:0020037 heme binding
GO:0031394 positive regulation of prostaglandin biosynthetic process
GO:0031622 positive regulation of fever generation
GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway
GO:0042759 long-chain fatty acid biosynthetic process
GO:0043005 neuron projection
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0046872 metal ion binding
GO:0050727 regulation of inflammatory response
GO:0051213 dioxygenase activity
GO:0071456 cellular response to hypoxia
GO:0071636 positive regulation of transforming growth factor beta production
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
GO:0090271 positive regulation of fibroblast growth factor production
GO:0090336 positive regulation of brown fat cell differentiation
GO:0090362 positive regulation of platelet-derived growth factor production
GO:0150077 regulation of neuroinflammatory response

Diseases

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Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
PTGS2Nos2BioGRID16373578 details
PTGS2VcpBioGRID24089527 details
PTGS2DroshaBioGRID25963660 details