Entity Details

Primary name TLR1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ9EPQ1
EntryNameTLR1_MOUSE
FullNameToll-like receptor 1
TaxID10090
Evidenceevidence at protein level
Length795
SequenceStatuscomplete
DateCreated2002-01-31
DateModified2021-06-02

Ontological Relatives

GenesTlr1

GO terms

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GOName
GO:0001774 microglial cell activation
GO:0001775 cell activation
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0004888 transmembrane signaling receptor activity
GO:0005794 Golgi apparatus
GO:0005887 integral component of plasma membrane
GO:0006952 defense response
GO:0006954 inflammatory response
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0016020 membrane
GO:0030670 phagocytic vesicle membrane
GO:0032493 response to bacterial lipoprotein
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034130 toll-like receptor 1 signaling pathway
GO:0034137 positive regulation of toll-like receptor 2 signaling pathway
GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex
GO:0035663 Toll-like receptor 2 binding
GO:0038023 signaling receptor activity
GO:0042116 macrophage activation
GO:0042495 detection of triacyl bacterial lipopeptide
GO:0042497 triacyl lipopeptide binding
GO:0042802 identical protein binding
GO:0045087 innate immune response
GO:0045121 membrane raft
GO:0045335 phagocytic vesicle
GO:0050135 NAD(P)+ nucleosidase activity
GO:0061809 NAD+ nucleotidase, cyclic ADP-ribose generating
GO:0071221 cellular response to bacterial lipopeptide
GO:0071723 lipopeptide binding
GO:0071727 cellular response to triacyl bacterial lipopeptide

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasmic vesicle
Golgi apparatus
Membrane raft

Domains

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DomainNameCategoryType
IPR000157 Toll/interleukin-1 receptor homology (TIR) domainDomainDomain
IPR000483 Cysteine-rich flanking region, C-terminalDomainDomain
IPR001611 Leucine-rich repeatRepeatRepeat
IPR003591 Leucine-rich repeat, typical subtypeRepeatRepeat
IPR017241 Toll-like receptorFamilyFamily
IPR027190 Toll-like receptor 1FamilyFamily
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily
IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

4 interactions