Entity Details

Primary name PTPN6
Entity type gene
Source Source Link

Details

PrimaryID5777
RefseqGene
SymbolPTPN6
Nameprotein tyrosine phosphatase non-receptor type 6
Chromosome12
Location12p13.31
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-19
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsPTN6_HUMAN

GO terms

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GOName
GO:0001784 phosphotyrosine residue binding
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin
GO:0004725 protein tyrosine phosphatase activity
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005911 cell-cell junction
GO:0006470 protein dephosphorylation
GO:0007186 G protein-coupled receptor signaling pathway
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 membrane
GO:0017124 SH3 domain binding
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0019901 protein kinase binding
GO:0030154 cell differentiation
GO:0030168 platelet activation
GO:0030220 platelet formation
GO:0031295 T cell costimulation
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032991 protein-containing complex
GO:0033277 abortive mitotic cell cycle
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0035556 intracellular signal transduction
GO:0035580 specific granule lumen
GO:0035855 megakaryocyte development
GO:0042105 alpha-beta T cell receptor complex
GO:0042130 negative regulation of T cell proliferation
GO:0042169 SH2 domain binding
GO:0042267 natural killer cell mediated cytotoxicity
GO:0042981 regulation of apoptotic process
GO:0043312 neutrophil degranulation
GO:0043407 negative regulation of MAP kinase activity
GO:0045577 regulation of B cell differentiation
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0050839 cell adhesion molecule binding
GO:0050853 B cell receptor signaling pathway
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0050900 leukocyte migration
GO:0051279 regulation of release of sequestered calcium ion into cytosol
GO:0060338 regulation of type I interferon-mediated signaling pathway
GO:0070062 extracellular exosome
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070527 platelet aggregation
GO:0071345 cellular response to cytokine stimulus
GO:0140031 phosphorylation-dependent protein binding
GO:1904724 tertiary granule lumen
GO:1905867 epididymis development
GO:2000045 regulation of G1/S transition of mitotic cell cycle

Diseases

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Interactions

6 interactions