Entity Details

Primary name PTPN11
Entity type gene
Source Source Link

Details

PrimaryID5781
RefseqGeneNG_007459
SymbolPTPN11
Nameprotein tyrosine phosphatase non-receptor type 11
Chromosome12
Location12q24.13
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-19
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsPTN11_HUMAN

GO terms

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GOName
GO:0000077 DNA damage checkpoint signaling
GO:0000187 obsolete activation of MAPK activity
GO:0001784 phosphotyrosine residue binding
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
GO:0005158 insulin receptor binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006641 triglyceride metabolic process
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0007411 axon guidance
GO:0007420 brain development
GO:0007507 heart development
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009755 hormone-mediated signaling pathway
GO:0019221 cytokine-mediated signaling pathway
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0021697 cerebellar cortex formation
GO:0030159 signaling receptor complex adaptor activity
GO:0030168 platelet activation
GO:0030220 platelet formation
GO:0030971 receptor tyrosine kinase binding
GO:0031295 T cell costimulation
GO:0031748 D1 dopamine receptor binding
GO:0032331 negative regulation of chondrocyte differentiation
GO:0032528 microvillus organization
GO:0032728 positive regulation of interferon-beta production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032991 protein-containing complex
GO:0033277 abortive mitotic cell cycle
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0033629 negative regulation of cell adhesion mediated by integrin
GO:0035264 multicellular organism growth
GO:0035265 organ growth
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0035855 megakaryocyte development
GO:0036302 atrioventricular canal development
GO:0038127 ERBB signaling pathway
GO:0042445 hormone metabolic process
GO:0042593 glucose homeostasis
GO:0043254 regulation of protein-containing complex assembly
GO:0043274 phospholipase binding
GO:0043560 insulin receptor substrate binding
GO:0044853 plasma membrane raft
GO:0045296 cadherin binding
GO:0045778 positive regulation of ossification
GO:0045931 positive regulation of mitotic cell cycle
GO:0046326 positive regulation of glucose import
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0046676 negative regulation of insulin secretion
GO:0046825 regulation of protein export from nucleus
GO:0046887 positive regulation of hormone secretion
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0048609 multicellular organismal reproductive process
GO:0048659 smooth muscle cell proliferation
GO:0048806 genitalia development
GO:0048839 inner ear development
GO:0048873 homeostasis of number of cells within a tissue
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050839 cell adhesion molecule binding
GO:0050900 leukocyte migration
GO:0051428 peptide hormone receptor binding
GO:0051463 negative regulation of cortisol secretion
GO:0051894 positive regulation of focal adhesion assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0060020 Bergmann glial cell differentiation
GO:0060125 negative regulation of growth hormone secretion
GO:0060325 face morphogenesis
GO:0060338 regulation of type I interferon-mediated signaling pathway
GO:0061582 intestinal epithelial cell migration
GO:0070102 interleukin-6-mediated signaling pathway
GO:0070301 cellular response to hydrogen peroxide
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071260 cellular response to mechanical stimulus
GO:0071345 cellular response to cytokine stimulus
GO:0071364 cellular response to epidermal growth factor stimulus
GO:1904385 cellular response to angiotensin
GO:1990314 cellular response to insulin-like growth factor stimulus
GO:1990782 protein tyrosine kinase binding

Diseases

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