Entity Details

Primary name REST
Entity type gene
Source Source Link

Details

PrimaryID5978
RefseqGeneNG_029447
SymbolREST
NameRE1 silencing transcription factor
Chromosome4
Location4q12
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-18
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsREST_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001666 response to hypoxia
GO:0002931 response to ischemia
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0008134 transcription factor binding
GO:0008285 negative regulation of cell population proliferation
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0017053 transcription repressor complex
GO:0032348 negative regulation of aldosterone biosynthetic process
GO:0035019 somatic stem cell population maintenance
GO:0035690 cellular response to drug
GO:0042802 identical protein binding
GO:0043065 positive regulation of apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043922 negative regulation by host of viral transcription
GO:0045665 negative regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045667 regulation of osteoblast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045955 negative regulation of calcium ion-dependent exocytosis
GO:0046676 negative regulation of insulin secretion
GO:0046872 metal ion binding
GO:0050768 negative regulation of neurogenesis
GO:0050885 neuromuscular process controlling balance
GO:0050910 detection of mechanical stimulus involved in sensory perception of sound
GO:0060088 auditory receptor cell stereocilium organization
GO:0060379 cardiac muscle cell myoblast differentiation
GO:0070933 histone H4 deacetylation
GO:0071257 cellular response to electrical stimulus
GO:0071385 cellular response to glucocorticoid stimulus
GO:0097150 neuronal stem cell population maintenance
GO:0099563 modification of synaptic structure
GO:1902459 positive regulation of stem cell population maintenance
GO:1903203 regulation of oxidative stress-induced neuron death
GO:1903204 negative regulation of oxidative stress-induced neuron death
GO:1903223 positive regulation of oxidative stress-induced neuron death
GO:2000065 negative regulation of cortisol biosynthetic process
GO:2000678 negative regulation of transcription regulatory region DNA binding
GO:2000706 negative regulation of dense core granule biogenesis
GO:2000740 negative regulation of mesenchymal stem cell differentiation
GO:2000798 negative regulation of amniotic stem cell differentiation

Diseases

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Interactions

6 interactions

InteractorPartnerSourcesPublicationsLink
RESTSin3bBioGRID10570134 details
RESTSin3aBioGRID10570134 details
RESTHdac1BioGRID10570134 details
RESTTbpBioGRID15197246 details
RESTGtf2bBioGRID15197246 details
RESTWizBioGRID, IntAct26496610 details