Entity Details

Primary name IKKB_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionO88351
EntryNameIKKB_MOUSE
FullNameInhibitor of nuclear factor kappa-B kinase subunit beta
TaxID10090
Evidenceevidence at protein level
Length757
SequenceStatuscomplete
DateCreated2001-06-01
DateModified2021-06-02

Ontological Relatives

GenesIkbkb

GO terms

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GOName
GO:0001782 B cell homeostasis
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007252 I-kappaB phosphorylation
GO:0008284 positive regulation of cell population proliferation
GO:0008384 IkappaB kinase activity
GO:0008385 IkappaB kinase complex
GO:0009898 cytoplasmic side of plasma membrane
GO:0010765 positive regulation of sodium ion transport
GO:0010976 positive regulation of neuron projection development
GO:0018105 peptidyl-serine phosphorylation
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0030866 cortical actin cytoskeleton organization
GO:0031175 neuron projection development
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0035509 negative regulation of myosin-light-chain-phosphatase activity
GO:0035631 CD40 receptor complex
GO:0042325 regulation of phosphorylation
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043231 intracellular membrane-bounded organelle
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046982 protein heterodimerization activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0061847 response to cholecystokinin
GO:0070498 interleukin-1-mediated signaling pathway
GO:0071356 cellular response to tumor necrosis factor
GO:0072659 protein localization to plasma membrane
GO:0097110 scaffold protein binding
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901216 positive regulation of neuron death
GO:1903140 regulation of establishment of endothelial barrier
GO:1903347 negative regulation of bicellular tight junction assembly
GO:1990459 transferrin receptor binding
GO:2001259 positive regulation of cation channel activity

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane raft
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR022007 I-kappa-kinase-beta NEMO binding domainDomainDomain
IPR041185 IKBKB, scaffold dimerization domainDomainDomain

Diseases

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Interactions

41 interactions

InteractorPartnerSourcesPublicationsLink
IKKB_MOUSESNX1_MOUSEIntAct15102471 details
IKKB_MOUSEBZW2_MOUSEIntAct15102471 details
IKKB_MOUSERACK1_MOUSEIntAct15102471 details
IKKB_MOUSE2AAA_MOUSEIntAct15102471 details
IKKB_MOUSESDC3_MOUSEIntAct15102471 details
IKKB_MOUSEGSTA3_MOUSEIntAct15102471 details
IKKB_MOUSEGMPPB_MOUSEIntAct15102471 details
IKKB_MOUSEKEAP1_MOUSEIntAct15102471 details
IKKB_MOUSEDDX5_MOUSEIntAct15102471 details
IKKB_MOUSENAGK_MOUSEIntAct15102471 details
IKKB_MOUSECREB3_MOUSEIntAct15102471 details
IKKB_MOUSECTNA1_MOUSEIntAct15102471 details
IKKB_MOUSENDKB_MOUSEIntAct15102471 details
IKKB_MOUSET2EB_MOUSEIntAct15102471 details
IKKB_MOUSESAS10_MOUSEIntAct15102471 details
IKKB_MOUSEIKBA_HUMANIntAct16291755 details
IKKB_MOUSENEMO_MOUSEBioGRID, DIP, IntAct, MINT, UniProt10748240 12808104 16306937 16378096 18216269 18266467 20211142 20404153 21606193 23825957 23871670 24240172 24270572 details
IKKB_MOUSEKEAP1_HUMANIntAct20600852 details
IKKB_MOUSENKX32_MOUSEBioGRID21606193 details
IKKB_MOUSEIKBA_MOUSEBioGRID21765415 21862579 22037600 details
IKKB_MOUSEIKBB_MOUSEBioGRID10593965 16260493 details
IKKB_MOUSEOPTN_MOUSEBioGRID21862579 details
IKKB_MOUSEKLH21_MOUSEBioGRID27387502 details
IKKB_MOUSEUBC_MOUSEBioGRID28190767 details
IKKB_MOUSEM3K1_MOUSEIntAct14500727 details
IKKB_MOUSEIKKA_MOUSEIntAct, MINT16498412 20434986 details
IKKB_MOUSEIKKB_MOUSEIntAct16319058 details
IKKB_MOUSEIRF7_MOUSEIntAct16612387 details
IKKB_MOUSESNP23_MOUSEBioGRID, IntAct18692471 23960234 details
IKKB_MOUSETNFA_HUMANDIP26649818 details
IKKB_MOUSEFBW1A_MOUSEBioGRID21606193 details
IKKB_MOUSERNF31_MOUSEBioGRID19136968 32325033 details
IKKB_MOUSEHOIL1_MOUSEBioGRID19136968 details
IKKB_MOUSETNR5_MOUSEBioGRID18635759 details
IKKB_MOUSETNR1A_MOUSEBioGRID16547522 29891719 32325033 details
IKKB_MOUSELIT1_MOUSEBioGRID22037600 details
IKKB_MOUSESASH1_MOUSEBioGRID23776175 details
IKKB_MOUSENEMO_HUMANBioGRID24266532 details
IKKB_MOUSERHOA_MOUSEBioGRID24240172 details
IKKB_MOUSESMN_MOUSEBioGRID28214532 details
IKKB_MOUSETNFA_MOUSEBioGRID29203883 details