Entity Details

Primary name SHMT2
Entity type gene
Source Source Link

Details

PrimaryID6472
RefseqGeneNG_029163
SymbolSHMT2
Nameserine hydroxymethyltransferase 2
Chromosome12
Location12q13.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1993-07-15
ModificationDate2021-06-19

Ontological Relatives

UniProt IDsGLYM_HUMAN

GO terms

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GOName
GO:0000900 translation repressor activity, mRNA regulatory element binding
GO:0002082 regulation of oxidative phosphorylation
GO:0003682 chromatin binding
GO:0004372 glycine hydroxymethyltransferase activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005758 mitochondrial intermembrane space
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0006544 glycine metabolic process
GO:0006563 L-serine metabolic process
GO:0006564 L-serine biosynthetic process
GO:0006565 L-serine catabolic process
GO:0006730 one-carbon metabolic process
GO:0008270 zinc ion binding
GO:0008284 positive regulation of cell population proliferation
GO:0008732 L-allo-threonine aldolase activity
GO:0009113 purine nucleobase biosynthetic process
GO:0015630 microtubule cytoskeleton
GO:0019264 glycine biosynthetic process from serine
GO:0030170 pyridoxal phosphate binding
GO:0034340 response to type I interferon
GO:0035999 tetrahydrofolate interconversion
GO:0042645 mitochondrial nucleoid
GO:0042803 protein homodimerization activity
GO:0046653 tetrahydrofolate metabolic process
GO:0046655 folic acid metabolic process
GO:0048027 mRNA 5'-UTR binding
GO:0050897 cobalt ion binding
GO:0051262 protein tetramerization
GO:0051289 protein homotetramerization
GO:0070062 extracellular exosome
GO:0070129 regulation of mitochondrial translation
GO:0070536 protein K63-linked deubiquitination
GO:0070552 BRISC complex
GO:0070905 serine binding
GO:1903715 regulation of aerobic respiration

Diseases

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Interactions

5 interactions

InteractorPartnerSourcesPublicationsLink
SHMT2Tnpo1BioGRID, IntAct26496610 details
SHMT2Ruvbl1BioGRID, IntAct26496610 details
SHMT2NfycBioGRID, IntAct26496610 details
SHMT2Ophn1BioGRID32203420 details
SHMT2Stard13BioGRID32203420 details