Entity Details

Primary name SNCA
Entity type gene
Source Source Link

Details

PrimaryID6622
RefseqGeneNG_011851
SymbolSNCA
Namesynuclein alpha
Chromosome4
Location4q22.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-24
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsSYUA_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000149 SNARE binding
GO:0000287 magnesium ion binding
GO:0000976 transcription cis-regulatory region binding
GO:0001774 microglial cell activation
GO:0001921 positive regulation of receptor recycling
GO:0003779 actin binding
GO:0004860 protein kinase inhibitor activity
GO:0005507 copper ion binding
GO:0005509 calcium ion binding
GO:0005543 phospholipid binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005764 lysosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0006469 negative regulation of protein kinase activity
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007268 chemical synaptic transmission
GO:0008198 ferrous iron binding
GO:0008270 zinc ion binding
GO:0010040 response to iron(II) ion
GO:0010517 regulation of phospholipase activity
GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0014059 regulation of dopamine secretion
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0016079 synaptic vesicle exocytosis
GO:0016082 synaptic vesicle priming
GO:0016234 inclusion body
GO:0016491 oxidoreductase activity
GO:0019894 kinesin binding
GO:0022898 regulation of transmembrane transporter activity
GO:0030424 axon
GO:0030426 growth cone
GO:0030544 Hsp70 protein binding
GO:0031115 negative regulation of microtubule polymerization
GO:0031623 receptor internalization
GO:0031648 protein destabilization
GO:0032026 response to magnesium ion
GO:0032410 negative regulation of transporter activity
GO:0032496 response to lipopolysaccharide
GO:0032769 negative regulation of monooxygenase activity
GO:0032991 protein-containing complex
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034341 response to interferon-gamma
GO:0034599 cellular response to oxidative stress
GO:0035067 negative regulation of histone acetylation
GO:0035493 SNARE complex assembly
GO:0035543 positive regulation of SNARE complex assembly
GO:0042393 histone binding
GO:0042416 dopamine biosynthetic process
GO:0042802 identical protein binding
GO:0043014 alpha-tubulin binding
GO:0043025 neuronal cell body
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043679 axon terminus
GO:0045807 positive regulation of endocytosis
GO:0045920 negative regulation of exocytosis
GO:0045921 positive regulation of exocytosis
GO:0048156 tau protein binding
GO:0048471 perinuclear region of cytoplasm
GO:0048488 synaptic vesicle endocytosis
GO:0050729 positive regulation of inflammatory response
GO:0050808 synapse organization
GO:0051219 phosphoprotein binding
GO:0051262 protein tetramerization
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051583 dopamine uptake involved in synaptic transmission
GO:0051585 negative regulation of dopamine uptake involved in synaptic transmission
GO:0051612 negative regulation of serotonin uptake
GO:0051621 regulation of norepinephrine uptake
GO:0051622 negative regulation of norepinephrine uptake
GO:0060732 positive regulation of inositol phosphate biosynthetic process
GO:0070495 negative regulation of thrombin-activated receptor signaling pathway
GO:0070555 response to interleukin-1
GO:0070840 dynein complex binding
GO:0071280 cellular response to copper ion
GO:0071872 cellular response to epinephrine stimulus
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0097435 supramolecular fiber organization
GO:0099512 supramolecular fiber
GO:1901214 regulation of neuron death
GO:1901215 negative regulation of neuron death
GO:1901216 positive regulation of neuron death
GO:1902957 negative regulation of mitochondrial electron transport, NADH to ubiquinone
GO:1903136 cuprous ion binding
GO:1903284 positive regulation of glutathione peroxidase activity
GO:1903285 positive regulation of hydrogen peroxide catabolic process
GO:1903421 regulation of synaptic vesicle recycling
GO:1903426 regulation of reactive oxygen species biosynthetic process
GO:1904715 negative regulation of chaperone-mediated autophagy
GO:1905606 regulation of presynapse assembly
GO:1990000 amyloid fibril formation

Diseases

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Interactions

175 interactions

InteractorPartnerSourcesPublicationsLink
SNCAYwhahMINT16096643 details
SNCATubb3BioGRID, IntAct11698390 18614564 details
SNCASlc6a3IntAct22163275 details
SNCACdc42ep2BioGRID18541383 details
SNCACamk2aBioGRID18614564 details
SNCAEpb41l2BioGRID18614564 details
SNCAActg1BioGRID18614564 details
SNCAMap6BioGRID18614564 details
SNCAVdac3BioGRID18614564 details
SNCAHk1BioGRID18614564 details
SNCACOX1BioGRID18614564 details
SNCATuba1aBioGRID11698390 details
SNCARab3aBioGRID15099020 details
SNCARab5aBioGRID15099020 details
SNCARab8aBioGRID15099020 details
SNCASncaBioGRID26839406 details
SNCAHsp90ab1IntAct20340160 details
SNCAEef1a1IntAct20340160 details
SNCAMybbp1aIntAct20340160 details
SNCACntfrIntAct20340160 details
SNCAVapaBioGRID, IntAct18614564 20340160 details
SNCASlc3a2IntAct20340160 details
SNCACct7IntAct20340160 details
SNCALactbBioGRID, IntAct18614564 details
SNCAH2ac21BioGRID, IntAct18614564 details
SNCAAtp5mdBioGRID, IntAct18614564 details
SNCAAtp6v1aBioGRID, IntAct18614564 details
SNCACnpBioGRID, IntAct18614564 details
SNCASypBioGRID, IntAct18614564 details
SNCACalm1BioGRID, IntAct18614564 details
SNCACalm2IntAct18614564 details
SNCACalm3IntAct18614564 details
SNCAThy1BioGRID, IntAct18614564 details
SNCARps10BioGRID, IntAct18614564 details
SNCAAldoaBioGRID, IntAct18614564 details
SNCACaskin1BioGRID, IntAct18614564 details
SNCATfamBioGRID, IntAct18614564 details
SNCAGnb2BioGRID, IntAct18614564 details
SNCAAgap2BioGRID, IntAct18614564 details
SNCAGnb1BioGRID, IntAct18614564 details
SNCARps7BioGRID, IntAct18614564 details
SNCAHnrnpa2b1BioGRID, IntAct18614564 details
SNCAAtp6v0d1BioGRID, IntAct18614564 details
SNCAAp2m1BioGRID, IntAct18614564 details
SNCAActr1aBioGRID, IntAct18614564 details
SNCAActr1bBioGRID, IntAct18614564 details
SNCAMap1bBioGRID, IntAct18614564 details
SNCAAp2a1BioGRID, IntAct18614564 details
SNCADynll2BioGRID, IntAct18614564 details
SNCAYwhagBioGRID, IntAct18614564 details
SNCAAp1b1BioGRID, IntAct18614564 details
SNCAYwhazBioGRID, IntAct18614564 details
SNCATubb6BioGRID, IntAct18614564 details
SNCATpppBioGRID, IntAct18614564 details
SNCACntn1BioGRID, IntAct18614564 details
SNCAAp2b1BioGRID, IntAct18614564 details
SNCATubb4aBioGRID, IntAct18614564 details
SNCAYwhaeBioGRID, IntAct18614564 details
SNCACltcBioGRID, IntAct18614564 details
SNCASrcin1BioGRID, IntAct18614564 details
SNCASlc25a1BioGRID, IntAct18614564 details
SNCATubb5BioGRID, IntAct18614564 details
SNCATuba4aBioGRID, IntAct18614564 details
SNCASlc1a3BioGRID, IntAct18614564 details
SNCASlc25a22BioGRID, IntAct18614564 details
SNCASptbn1BioGRID, IntAct18614564 details
SNCANeflBioGRID, IntAct18614564 details
SNCAMap1lc3aBioGRID, IntAct18614564 details
SNCACapza2BioGRID, IntAct18614564 details
SNCADctn2BioGRID, IntAct18614564 details
SNCABcas1BioGRID, IntAct18614564 details
SNCATrim3BioGRID, IntAct18614564 details
SNCAEpb41l3BioGRID, IntAct18614564 details
SNCAMyl12bBioGRID, IntAct18614564 details
SNCAInaBioGRID, IntAct18614564 details
SNCAActbBioGRID, IntAct18614564 details
SNCADynll1BioGRID, IntAct18614564 details
SNCATmod2BioGRID, IntAct18614564 details
SNCAAnk2BioGRID, IntAct18614564 details
SNCACtnna2BioGRID, IntAct18614564 details
SNCAMyo5aBioGRID, IntAct18614564 details
SNCAMyh10BioGRID, IntAct18614564 details
SNCACtnnb1BioGRID, IntAct18614564 details
SNCACamk2dBioGRID, IntAct18614564 details
SNCACamk2bBioGRID, IntAct18614564 details
SNCAMark1BioGRID, IntAct18614564 details
SNCAPpp1caBioGRID, IntAct18614564 details
SNCABrsk1BioGRID, IntAct18614564 details
SNCAMark2BioGRID, IntAct18614564 details
SNCANdufa6BioGRID, IntAct18614564 details
SNCANdufs7BioGRID, IntAct18614564 details
SNCAUqcrc1BioGRID, IntAct18614564 details
SNCANdufb10BioGRID, IntAct18614564 details
SNCANdufa5BioGRID, IntAct18614564 details
SNCANdufb6BioGRID, IntAct18614564 details
SNCATomm40BioGRID, IntAct18614564 details
SNCAND1BioGRID, IntAct18614564 details
SNCANdufv1BioGRID, IntAct18614564 details
SNCACox5aBioGRID, IntAct18614564 details
SNCAUqcrqBioGRID, IntAct18614564 details
SNCAUqcrfs1BioGRID, IntAct18614564 details
SNCACox7a2BioGRID, IntAct18614564 details
SNCANdufb9BioGRID, IntAct18614564 details
SNCANdufs2BioGRID, IntAct18614564 details
SNCANdufs1BioGRID, IntAct18614564 details
SNCAND2BioGRID, IntAct18614564 details
SNCASamm50BioGRID, IntAct18614564 details
SNCANdufa12BioGRID, IntAct18614564 details
SNCANdufs5BioGRID, IntAct18614564 details
SNCACox6a1BioGRID, IntAct18614564 details
SNCAND5BioGRID, IntAct18614564 details
SNCACyc1BioGRID, IntAct18614564 details
SNCACox6cBioGRID, IntAct18614564 details
SNCANdufb3BioGRID, IntAct18614564 details
SNCANdufs8BioGRID, IntAct18614564 details
SNCANdufa8BioGRID, IntAct18614564 details
SNCANdufs3BioGRID, IntAct18614564 details
SNCANdufa10BioGRID, IntAct18614564 details
SNCANdufs4BioGRID, IntAct18614564 details
SNCAStxbp1BioGRID, IntAct18614564 details
SNCANdufb5BioGRID, IntAct18614564 details
SNCANdufc2BioGRID, IntAct18614564 details
SNCARmdn3BioGRID, IntAct18614564 details
SNCAUqcrc2BioGRID, IntAct18614564 details
SNCANdufb8BioGRID, IntAct18614564 details
SNCANdufa13BioGRID, IntAct18614564 details
SNCANdufb4bIntAct18614564 details
SNCANdufb4BioGRID, IntAct18614564 details
SNCANdufb7BioGRID, IntAct18614564 details
SNCAND4BioGRID, IntAct18614564 details
SNCANdufb11BioGRID, IntAct18614564 details
SNCACOX2BioGRID, IntAct18614564 details
SNCANdufa9BioGRID, IntAct18614564 details
SNCACox7a2lBioGRID, IntAct18614564 details
SNCANdufv2BioGRID, IntAct18614564 details
SNCAUqcr10BioGRID, IntAct18614564 details
SNCAGkBioGRID, IntAct18614564 details
SNCACox6b1BioGRID, IntAct18614564 details
SNCAAtp5pbBioGRID, IntAct18614564 details
SNCAAtp5c1BioGRID, IntAct18614564 details
SNCAPhbBioGRID, IntAct18614564 details
SNCASyt2BioGRID, IntAct18614564 details
SNCAIcam5BioGRID, IntAct18614564 details
SNCAAtp6v1b2BioGRID, IntAct18614564 details
SNCAAtp6v0a1BioGRID, IntAct18614564 details
SNCAGlulBioGRID, IntAct18614564 details
SNCAImmtBioGRID, IntAct18614564 details
SNCAChchd3BioGRID, IntAct18614564 details
SNCAMgst3BioGRID, IntAct18614564 details
SNCAPoldip3BioGRID, IntAct18614564 details
SNCAGnao1BioGRID, IntAct18614564 details
SNCASlc1a2BioGRID, IntAct18614564 details
SNCAPhb2BioGRID, IntAct18614564 details
SNCACd47BioGRID, IntAct18614564 details
SNCANdufa2BioGRID, IntAct18614564 details
SNCAStx1aBioGRID, IntAct18614564 details
SNCATomm22BioGRID, IntAct18614564 details
SNCAMap1aBioGRID, IntAct18614564 details
SNCAHspa9BioGRID, IntAct18614564 details
SNCAHspa5BioGRID, IntAct18614564 details
SNCASlc25a12BioGRID, IntAct18614564 details
SNCAMtch2BioGRID, IntAct18614564 details
SNCASlc25a11BioGRID, IntAct18614564 details
SNCASlc25a13BioGRID, IntAct18614564 details
SNCASlc25a3BioGRID, IntAct18614564 details
SNCAAtp5hBioGRID, IntAct18614564 details
SNCAMap4BioGRID, IntAct18614564 details
SNCAMap7d1BioGRID, IntAct18614564 details
SNCAKcnab2BioGRID, IntAct18614564 details
SNCAKcnab1BioGRID, IntAct18614564 details
SNCAVdac1BioGRID, IntAct18614564 details
SNCAMap2BioGRID, IntAct18614564 details
SNCAVdac2BioGRID, IntAct18614564 details
SNCASnap25UniProt20798282 details
SNCAVamp2UniProt20798282 details