Entity Details

Primary name BRAF
Entity type gene
Source Source Link

Details

PrimaryID673
RefseqGeneNG_007873
SymbolBRAF
NameB-Raf proto-oncogene, serine/threonine kinase
Chromosome7
Location7q34
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1995-03-30
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsBRAF_HUMAN

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000186 obsolete activation of MAPKK activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005509 calcium ion binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0009887 animal organ morphogenesis
GO:0010628 positive regulation of gene expression
GO:0010828 positive regulation of glucose transmembrane transport
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070413 trehalose metabolism in response to stress
GO:0071277 cellular response to calcium ion
GO:0090150 establishment of protein localization to membrane
GO:0097110 scaffold protein binding
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Diseases

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Interactions

5 interactions

InteractorPartnerSourcesPublicationsLink
BRAFRgs12MINT17380122 details
BRAFKsr1MINT22510884 details
BRAFRaf1MINT22510884 details
BRAFArafMINT22510884 details
BRAFVps4bBioGRID, IntAct26496610 details