Entity Details

Primary name SHIP1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ9ES52
EntryNameSHIP1_MOUSE
FullNamePhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
TaxID10090
Evidenceevidence at protein level
Length1191
SequenceStatuscomplete
DateCreated2007-09-11
DateModified2021-06-02

Ontological Relatives

GenesInpp5d

GO terms

Show/Hide Table
GOName
GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0004445 inositol-polyphosphate 5-phosphatase activity
GO:0005829 cytosol
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0006915 apoptotic process
GO:0008285 negative regulation of cell population proliferation
GO:0008340 determination of adult lifespan
GO:0009968 negative regulation of signal transduction
GO:0016064 immunoglobulin mediated immune response
GO:0017124 SH3 domain binding
GO:0030487 inositol-4,5-bisphosphate 5-phosphatase activity
GO:0030853 negative regulation of granulocyte differentiation
GO:0030863 cortical cytoskeleton
GO:0030889 negative regulation of B cell proliferation
GO:0032715 negative regulation of interleukin-6 production
GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
GO:0034594 phosphatidylinositol trisphosphate phosphatase activity
GO:0035556 intracellular signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0045121 membrane raft
GO:0045579 positive regulation of B cell differentiation
GO:0045621 positive regulation of lymphocyte differentiation
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045656 negative regulation of monocyte differentiation
GO:0045659 negative regulation of neutrophil differentiation
GO:0045671 negative regulation of osteoclast differentiation
GO:0045779 negative regulation of bone resorption
GO:0046856 phosphatidylinositol dephosphorylation
GO:0050777 negative regulation of immune response
GO:0050869 negative regulation of B cell activation
GO:0051425 PTB domain binding
GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity
GO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Cytoplasm
Membrane raft

Domains

Show/Hide Table
DomainNameCategoryType
IPR000300 Inositol polyphosphate-related phosphataseDomainDomain
IPR000980 SH2 domainDomainDomain
IPR005135 Endonuclease/exonuclease/phosphataseDomainDomain
IPR036691 Endonuclease/exonuclease/phosphatase superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table