Entity Details

Primary name ADAM17
Entity type gene
Source Source Link

Details

PrimaryID6868
RefseqGeneNG_029873
SymbolADAM17
NameADAM metallopeptidase domain 17
Chromosome2
Location2p25.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-12-11
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsADA17_HUMAN

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001666 response to hypoxia
GO:0001934 positive regulation of protein phosphorylation
GO:0002446 neutrophil mediated immunity
GO:0002467 germinal center formation
GO:0002690 positive regulation of leukocyte chemotaxis
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0005112 Notch binding
GO:0005138 interleukin-6 receptor binding
GO:0005178 integrin binding
GO:0005737 cytoplasm
GO:0005788 endoplasmic reticulum lumen
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006508 proteolysis
GO:0006509 membrane protein ectodomain proteolysis
GO:0007155 cell adhesion
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007219 Notch signaling pathway
GO:0007220 Notch receptor processing
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0008284 positive regulation of cell population proliferation
GO:0009986 cell surface
GO:0010820 positive regulation of T cell chemotaxis
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0016485 protein processing
GO:0017124 SH3 domain binding
GO:0030165 PDZ domain binding
GO:0030183 B cell differentiation
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031293 membrane protein intracellular domain proteolysis
GO:0032496 response to lipopolysaccharide
GO:0032722 positive regulation of chemokine production
GO:0033025 regulation of mast cell apoptotic process
GO:0033077 T cell differentiation in thymus
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0033627 cell adhesion mediated by integrin
GO:0035313 wound healing, spreading of epidermal cells
GO:0035624 receptor transactivation
GO:0042493 response to drug
GO:0042987 amyloid precursor protein catabolic process
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045121 membrane raft
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045741 positive regulation of epidermal growth factor-activated receptor activity
GO:0046872 metal ion binding
GO:0048536 spleen development
GO:0048870 cell motility
GO:0050830 defense response to Gram-positive bacterium
GO:0051272 positive regulation of cellular component movement
GO:0071403 cellular response to high density lipoprotein particle stimulus
GO:0120163 negative regulation of cold-induced thermogenesis
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:1902945 metalloendopeptidase activity involved in amyloid precursor protein catabolic process
GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway
GO:1905564 positive regulation of vascular endothelial cell proliferation

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
ADAM17Rhbdf2DIP22246777 details
ADAM17Sgo2aBioGRID, IntAct26496610 details