Entity Details

Primary name BTK
Entity type gene
Source Source Link

Details

PrimaryID695
RefseqGeneNG_009616
SymbolBTK
NameBruton tyrosine kinase
ChromosomeX
LocationXq22.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-06
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsBTK_HUMAN

GO terms

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GOName
GO:0001805 positive regulation of type III hypersensitivity
GO:0001812 positive regulation of type I hypersensitivity
GO:0001818 negative regulation of cytokine production
GO:0002250 adaptive immune response
GO:0002344 B cell affinity maturation
GO:0002553 histamine secretion by mast cell
GO:0002721 regulation of B cell cytokine production
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002902 regulation of B cell apoptotic process
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007498 mesoderm development
GO:0016004 phospholipase activator activity
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019722 calcium-mediated signaling
GO:0030889 negative regulation of B cell proliferation
GO:0031410 cytoplasmic vesicle
GO:0034614 cellular response to reactive oxygen species
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042113 B cell activation
GO:0042802 identical protein binding
GO:0043274 phospholipase binding
GO:0045087 innate immune response
GO:0045121 membrane raft
GO:0045579 positive regulation of B cell differentiation
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0048469 cell maturation
GO:0048471 perinuclear region of cytoplasm
GO:0050853 B cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0071226 cellular response to molecule of fungal origin
GO:0097190 apoptotic signaling pathway
GO:0098761 cellular response to interleukin-7

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
BTKMbpBioGRID, MINT18067320 details
BTKBlnkMINT10556826 details