Entity Details

Primary name TGFBR1
Entity type gene
Source Source Link

Details

PrimaryID7046
RefseqGeneNG_007461
SymbolTGFBR1
Nametransforming growth factor beta receptor 1
Chromosome9
Location9q22.33
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-18
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsTGFR1_HUMAN

GO terms

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GOName
GO:0000186 obsolete activation of MAPKK activity
GO:0001501 skeletal system development
GO:0001701 in utero embryonic development
GO:0001822 kidney development
GO:0001824 blastocyst development
GO:0001837 epithelial to mesenchymal transition
GO:0001937 negative regulation of endothelial cell proliferation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002088 lens development in camera-type eye
GO:0003222 ventricular trabecula myocardium morphogenesis
GO:0003223 ventricular compact myocardium morphogenesis
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005024 transforming growth factor beta-activated receptor activity
GO:0005025 transforming growth factor beta receptor activity, type I
GO:0005114 type II transforming growth factor beta receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005923 bicellular tight junction
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007399 nervous system development
GO:0007507 heart development
GO:0008284 positive regulation of cell population proliferation
GO:0008354 germ cell migration
GO:0008584 male gonad development
GO:0009791 post-embryonic development
GO:0009952 anterior/posterior pattern specification
GO:0009986 cell surface
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0010717 regulation of epithelial to mesenchymal transition
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0016020 membrane
GO:0016361 activin receptor activity, type I
GO:0016579 protein deubiquitination
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0030199 collagen fibril organization
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031396 regulation of protein ubiquitination
GO:0032331 negative regulation of chondrocyte differentiation
GO:0032924 activin receptor signaling pathway
GO:0035556 intracellular signal transduction
GO:0042060 wound healing
GO:0042118 endothelial cell activation
GO:0043062 extracellular structure organization
GO:0043235 receptor complex
GO:0043393 regulation of protein binding
GO:0043542 endothelial cell migration
GO:0045121 membrane raft
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046332 SMAD binding
GO:0046872 metal ion binding
GO:0048179 activin receptor complex
GO:0048185 activin binding
GO:0048538 thymus development
GO:0048663 neuron fate commitment
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048705 skeletal system morphogenesis
GO:0048762 mesenchymal cell differentiation
GO:0048844 artery morphogenesis
GO:0048870 cell motility
GO:0050431 transforming growth factor beta binding
GO:0051272 positive regulation of cellular component movement
GO:0051491 positive regulation of filopodium assembly
GO:0051496 positive regulation of stress fiber assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0060017 parathyroid gland development
GO:0060021 roof of mouth development
GO:0060037 pharyngeal system development
GO:0060043 regulation of cardiac muscle cell proliferation
GO:0060317 cardiac epithelial to mesenchymal transition
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0060391 positive regulation of SMAD protein signal transduction
GO:0060412 ventricular septum morphogenesis
GO:0060978 angiogenesis involved in coronary vascular morphogenesis
GO:0060982 coronary artery morphogenesis
GO:0070411 I-SMAD binding
GO:0070723 response to cholesterol
GO:0071363 cellular response to growth factor stimulus
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:1905007 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
GO:1905075 positive regulation of tight junction disassembly
GO:1905223 epicardium morphogenesis
GO:2001235 positive regulation of apoptotic signaling pathway
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Diseases

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Interactions

110 interactions

InteractorPartnerSourcesPublicationsLink
TGFBR1Ubxn1MINT15761153 details
TGFBR1Rnf5MINT15761153 details
TGFBR1Plk4MINT15761153 details
TGFBR1Nat8MINT15761153 details
TGFBR1Smad7BioGRID15761153 9738003 details
TGFBR1RhodBioGRID, MINT15761153 details
TGFBR1Arl4dBioGRID, MINT15761153 details
TGFBR1Fbxl12BioGRID, MINT15761153 details
TGFBR1Pard6aBioGRID, MINT15761153 details
TGFBR1Cdc42ep4BioGRID, MINT15761153 details
TGFBR1Rab13BioGRID, MINT15761153 details
TGFBR1Rhebl1BioGRID, MINT15761153 details
TGFBR1AurkbBioGRID, MINT15761153 details
TGFBR1UbdBioGRID, MINT15761153 details
TGFBR1Rab3bBioGRID, MINT15761153 details
TGFBR1Nek8BioGRID, MINT15761153 details
TGFBR1FanclBioGRID, MINT15761153 details
TGFBR1Plekhb1BioGRID, MINT15761153 details
TGFBR1Chn1BioGRID, MINT15761153 details
TGFBR1Rgs19BioGRID, MINT15761153 details
TGFBR1Nkiras1BioGRID15761153 details
TGFBR1Rasd2BioGRID15761153 details
TGFBR1Rab33bBioGRID15761153 details
TGFBR1Rab6bBioGRID15761153 details
TGFBR1Rab38BioGRID15761153 details
TGFBR1Rhobtb1BioGRID15761153 details
TGFBR1Git2BioGRID15761153 details
TGFBR1Gna13BioGRID15761153 details
TGFBR1Arhgap31BioGRID15761153 details
TGFBR1Chn2BioGRID15761153 details
TGFBR1BcrBioGRID15761153 details
TGFBR1Atg16l1BioGRID15761153 details
TGFBR1Prpf4BioGRID15761153 details
TGFBR1Cdc20BioGRID15761153 details
TGFBR1Katnb1BioGRID15761153 details
TGFBR1Nup37BioGRID15761153 details
TGFBR1Gnb3BioGRID15761153 details
TGFBR1Wsb1BioGRID15761153 details
TGFBR1PrebBioGRID15761153 details
TGFBR1Wdr13BioGRID15761153 details
TGFBR1Wdr61BioGRID15761153 details
TGFBR1Gnb2BioGRID15761153 details
TGFBR1Fbxw5BioGRID15761153 details
TGFBR1Csnk2a2BioGRID15761153 details
TGFBR1Cdkl1BioGRID15761153 details
TGFBR1Nek6BioGRID15761153 details
TGFBR1Stk35BioGRID15761153 details
TGFBR1Tssk5BioGRID15761153 details
TGFBR1Mknk2BioGRID15761153 details
TGFBR1Map2k3BioGRID15761153 details
TGFBR1IkbkbBioGRID15761153 details
TGFBR1Cdk4BioGRID15761153 details
TGFBR1Eif2ak4BioGRID15761153 details
TGFBR1Dapk2BioGRID15761153 details
TGFBR1Csnk1dBioGRID15761153 details
TGFBR1Nuak2BioGRID15761153 details
TGFBR1Tssk3BioGRID15761153 details
TGFBR1Uhmk1BioGRID15761153 details
TGFBR1Eif2ak1BioGRID15761153 details
TGFBR1Cdk14BioGRID15761153 details
TGFBR1Cdk17BioGRID15761153 details
TGFBR1Cdk6BioGRID15761153 details
TGFBR1Tgfbr1BioGRID15761153 details
TGFBR1Bmpr2BioGRID15761153 details
TGFBR1Stub1BioGRID15761153 details
TGFBR1Ttc1BioGRID15761153 details
TGFBR1Enc1BioGRID15761153 details
TGFBR1Klhl1BioGRID15761153 details
TGFBR1Skap2BioGRID15761153 details
TGFBR1ItkBioGRID15761153 details
TGFBR1Sntg1BioGRID15761153 details
TGFBR1PlekBioGRID15761153 details
TGFBR1Arhgap15BioGRID15761153 details
TGFBR1Arhgef6BioGRID15761153 details
TGFBR1Dusp10BioGRID15761153 details
TGFBR1Dusp6BioGRID15761153 details
TGFBR1IlkapBioGRID15761153 details
TGFBR1Ppp3ccBioGRID15761153 details
TGFBR1Ppp1caBioGRID15761153 details
TGFBR1Ppp6cBioGRID15761153 details
TGFBR1Rnf130BioGRID15761153 details
TGFBR1Rnf138BioGRID15761153 details
TGFBR1Noxo1BioGRID15761153 details
TGFBR1Naa20BioGRID15761153 details
TGFBR1Samd8BioGRID15761153 details
TGFBR1Fkbp1bBioGRID15761153 details
TGFBR1Fkbp1aBioGRID15761153 details
TGFBR1Irf7BioGRID15761153 details
TGFBR1Efna1BioGRID15761153 details
TGFBR1Rhpn2BioGRID15761153 details
TGFBR1RtknBioGRID15761153 details
TGFBR1Stx8BioGRID15761153 details
TGFBR1RrhBioGRID15761153 details
TGFBR1OclnBioGRID15761153 details
TGFBR1RhoaBioGRID15761153 details
TGFBR1RhohBioGRID15761153 details
TGFBR1RhojBioGRID15761153 details
TGFBR1Rab34BioGRID15761153 details
TGFBR1UbbBioGRID15761153 details
TGFBR1Rps27aBioGRID15761153 details
TGFBR1Usp45BioGRID15761153 details
TGFBR1Usp21BioGRID15761153 details
TGFBR1Ube2e3BioGRID15761153 details
TGFBR1Fbxo3BioGRID15761153 details
TGFBR1Fbxo34BioGRID15761153 details
TGFBR1Fbxo24BioGRID15761153 details
TGFBR1Cul5BioGRID15761153 details
TGFBR1Anapc5BioGRID15761153 details
TGFBR1Wwp2BioGRID15761153 details
TGFBR1Rap2aBioGRID15761153 details