Entity Details

Primary name THBS1
Entity type gene
Source Source Link

Details

PrimaryID7057
RefseqGene
SymbolTHBS1
Namethrombospondin 1
Chromosome15
Location15q14
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-18
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsTSP1_HUMAN

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001666 response to hypoxia
GO:0001786 phosphatidylserine binding
GO:0001937 negative regulation of endothelial cell proliferation
GO:0001953 negative regulation of cell-matrix adhesion
GO:0001968 fibronectin binding
GO:0002040 sprouting angiogenesis
GO:0002544 chronic inflammatory response
GO:0002576 platelet degranulation
GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0002605 negative regulation of dendritic cell antigen processing and presentation
GO:0005178 integrin binding
GO:0005201 extracellular matrix structural constituent
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005577 fibrinogen complex
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0006986 response to unfolded protein
GO:0007155 cell adhesion
GO:0008201 heparin binding
GO:0008284 positive regulation of cell population proliferation
GO:0009612 response to mechanical stimulus
GO:0009749 response to glucose
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010595 positive regulation of endothelial cell migration
GO:0010596 negative regulation of endothelial cell migration
GO:0010748 negative regulation of long-chain fatty acid import across plasma membrane
GO:0010751 negative regulation of nitric oxide mediated signal transduction
GO:0010754 negative regulation of cGMP-mediated signaling
GO:0010757 negative regulation of plasminogen activation
GO:0010759 positive regulation of macrophage chemotaxis
GO:0010763 positive regulation of fibroblast migration
GO:0016477 cell migration
GO:0016525 negative regulation of angiogenesis
GO:0016529 sarcoplasmic reticulum
GO:0017134 fibroblast growth factor binding
GO:0018149 peptide cross-linking
GO:0030141 secretory granule
GO:0030169 low-density lipoprotein particle binding
GO:0030194 positive regulation of blood coagulation
GO:0030198 extracellular matrix organization
GO:0030335 positive regulation of cell migration
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0031012 extracellular matrix
GO:0031091 platelet alpha granule
GO:0031093 platelet alpha granule lumen
GO:0032026 response to magnesium ion
GO:0032570 response to progesterone
GO:0032695 negative regulation of interleukin-12 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032914 positive regulation of transforming growth factor beta1 production
GO:0033574 response to testosterone
GO:0034605 cellular response to heat
GO:0034976 response to endoplasmic reticulum stress
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042327 positive regulation of phosphorylation
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0043032 positive regulation of macrophage activation
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043236 laminin binding
GO:0043394 proteoglycan binding
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0043652 engulfment of apoptotic cell
GO:0045652 regulation of megakaryocyte differentiation
GO:0045727 positive regulation of translation
GO:0045766 positive regulation of angiogenesis
GO:0048266 behavioral response to pain
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050431 transforming growth factor beta binding
GO:0050921 positive regulation of chemotaxis
GO:0051592 response to calcium ion
GO:0051895 negative regulation of focal adhesion assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0051918 negative regulation of fibrinolysis
GO:0062023 collagen-containing extracellular matrix
GO:0070051 fibrinogen binding
GO:0070052 collagen V binding
GO:0070062 extracellular exosome
GO:0071356 cellular response to tumor necrosis factor
GO:0071363 cellular response to growth factor stimulus
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:1903671 negative regulation of sprouting angiogenesis
GO:2000353 positive regulation of endothelial cell apoptotic process
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2001027 negative regulation of endothelial cell chemotaxis
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
THBS1Tubb5BioGRID, IntAct20360068 details
THBS1Creld2IntAct23956175 details