Entity Details

Primary name TOP1
Entity type gene
Source Source Link

Details

PrimaryID7150
RefseqGeneNG_012262
SymbolTOP1
NameDNA topoisomerase I
Chromosome20
Location20q12
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1990-06-22
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsTOP1_HUMAN

GO terms

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GOName
GO:0000932 P-body
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001650 fibrillar center
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003697 single-stranded DNA binding
GO:0003723 RNA binding
GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0006260 DNA replication
GO:0006265 DNA topological change
GO:0006338 chromatin remodeling
GO:0007059 chromosome segregation
GO:0007623 circadian rhythm
GO:0012501 programmed cell death
GO:0016032 viral process
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0019904 protein domain specific binding
GO:0032922 circadian regulation of gene expression
GO:0032993 protein-DNA complex
GO:0040016 embryonic cleavage
GO:0042493 response to drug
GO:0043204 perikaryon
GO:0097100 supercoiled DNA binding

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
TOP1Prdm16MINT30462309 details
TOP1MecomMINT30462309 details