Entity Details

Primary name TOP2A
Entity type gene
Source Source Link

Details

PrimaryID7153
RefseqGeneNG_027678
SymbolTOP2A
NameDNA topoisomerase II alpha
Chromosome17
Location17q21.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1992-03-20
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsTOP2A_HUMAN

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0000712 resolution of meiotic recombination intermediates
GO:0000775 chromosome, centromeric region
GO:0000793 condensed chromosome
GO:0000819 sister chromatid segregation
GO:0002244 hematopoietic progenitor cell differentiation
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003723 RNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0006265 DNA topological change
GO:0006266 DNA ligation
GO:0006974 cellular response to DNA damage stimulus
GO:0007059 chromosome segregation
GO:0007143 female meiotic nuclear division
GO:0008022 protein C-terminus binding
GO:0008094 ATPase, acting on DNA
GO:0008301 DNA binding, bending
GO:0009330 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
GO:0019899 enzyme binding
GO:0030263 apoptotic chromosome condensation
GO:0032991 protein-containing complex
GO:0040016 embryonic cleavage
GO:0042752 regulation of circadian rhythm
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043065 positive regulation of apoptotic process
GO:0043130 ubiquitin binding
GO:0045870 positive regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046982 protein heterodimerization activity
GO:0048511 rhythmic process
GO:1905463 negative regulation of DNA duplex unwinding
GO:1990904 ribonucleoprotein complex

Diseases

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Interactions

10 interactions

InteractorPartnerSourcesPublicationsLink
TOP2AAireIntAct20085707 details
TOP2ATop2bBioGRID, IntAct20360068 details
TOP2ACbx1BioGRID, IntAct26496610 details
TOP2AAtrxBioGRID, IntAct26496610 details
TOP2ARrbp1BioGRID, IntAct26496610 details
TOP2ASpire2BioGRID, IntAct26496610 details
TOP2AEif3eBioGRID, IntAct26496610 details
TOP2AEif3iBioGRID, IntAct26496610 details
TOP2APrdm16MINT30462309 details
TOP2AMecomMINT30462309 details