Entity Details

Primary name TSC2
Entity type gene
Source Source Link

Details

PrimaryID7249
RefseqGeneNG_005895
SymbolTSC2
NameTSC complex subunit 2
Chromosome16
Location16p13.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1993-10-20
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsTSC2_HUMAN

GO terms

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GOName
GO:0001843 neural tube closure
GO:0005096 GTPase activator activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0006469 negative regulation of protein kinase activity
GO:0006606 protein import into nucleus
GO:0006897 endocytosis
GO:0007507 heart development
GO:0008104 protein localization
GO:0008285 negative regulation of cell population proliferation
GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016032 viral process
GO:0016192 vesicle-mediated transport
GO:0016239 positive regulation of macroautophagy
GO:0019902 phosphatase binding
GO:0030100 regulation of endocytosis
GO:0030178 negative regulation of Wnt signaling pathway
GO:0031267 small GTPase binding
GO:0032007 negative regulation of TOR signaling
GO:0033596 TSC1-TSC2 complex
GO:0042803 protein homodimerization activity
GO:0043276 anoikis
GO:0043491 protein kinase B signaling
GO:0046626 regulation of insulin receptor signaling pathway
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048471 perinuclear region of cytoplasm
GO:0050918 positive chemotaxis
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051726 regulation of cell cycle
GO:0051879 Hsp90 protein binding
GO:0051898 negative regulation of protein kinase B signaling
GO:1901525 negative regulation of mitophagy

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
TSC2Tsc1BioGRID, IntAct26496610 details
TSC2Tbc1d7BioGRID, IntAct26496610 details