Entity Details

Primary name ZAP70
Entity type gene
Source Source Link

Details

PrimaryID7535
RefseqGeneNG_007727
SymbolZAP70
Namezeta chain of T cell receptor associated protein kinase 70
Chromosome2
Location2q11.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-03-20
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsZAP70_HUMAN

GO terms

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GOName
GO:0001772 immunological synapse
GO:0001784 phosphotyrosine residue binding
GO:0002250 adaptive immune response
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005102 signaling receptor binding
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0006468 protein phosphorylation
GO:0006955 immune response
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030154 cell differentiation
GO:0030217 T cell differentiation
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0035556 intracellular signal transduction
GO:0042101 T cell receptor complex
GO:0042110 T cell activation
GO:0042113 B cell activation
GO:0043366 beta selection
GO:0045059 positive thymic T cell selection
GO:0045060 negative thymic T cell selection
GO:0045087 innate immune response
GO:0045582 positive regulation of T cell differentiation
GO:0046638 positive regulation of alpha-beta T cell differentiation
GO:0046641 positive regulation of alpha-beta T cell proliferation
GO:0046777 protein autophosphorylation
GO:0050850 positive regulation of calcium-mediated signaling
GO:0050852 T cell receptor signaling pathway
GO:0070489 T cell aggregation
GO:0072678 T cell migration

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
ZAP70Cd3eBioGRID11855827 details
ZAP70Ubash3bMINT24256567 details