Entity Details

Primary name ASAH2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ9JHE3
EntryNameASAH2_MOUSE
FullNameNeutral ceramidase
TaxID10090
Evidenceevidence at protein level
Length756
SequenceStatuscomplete
DateCreated2006-07-25
DateModified2021-06-02

Ontological Relatives

GenesAsah2

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0006670 sphingosine metabolic process
GO:0006672 ceramide metabolic process
GO:0006915 apoptotic process
GO:0007346 regulation of mitotic cell cycle
GO:0008270 zinc ion binding
GO:0010033 response to organic substance
GO:0016020 membrane
GO:0017040 N-acylsphingosine amidohydrolase activity
GO:0042759 long-chain fatty acid biosynthetic process
GO:0044241 lipid digestion
GO:0046512 sphingosine biosynthetic process
GO:0046513 ceramide biosynthetic process
GO:0046514 ceramide catabolic process
GO:0070062 extracellular exosome
GO:0070774 phytoceramidase activity
GO:0071345 cellular response to cytokine stimulus
GO:0071633 dihydroceramidase activity
GO:0102121 ceramidase activity
GO:2001234 negative regulation of apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Golgi apparatus membrane
Membrane
Membrane raft
Mitochondrion
Secreted

Domains

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DomainNameCategoryType
IPR006823 Neutral/alkaline nonlysosomal ceramidaseFamilyFamily
IPR031329 Neutral/alkaline non-lysosomal ceramidase, N-terminalDomainDomain
IPR031331 Neutral/alkaline non-lysosomal ceramidase, C-terminalDomainDomain
IPR038445 Neutral ceramidase, C-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

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