Entity Details

Primary name ACTN2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ9JI91
EntryNameACTN2_MOUSE
FullNameAlpha-actinin-2
TaxID10090
Evidenceevidence at protein level
Length894
SequenceStatuscomplete
DateCreated2001-02-21
DateModified2021-06-02

Ontological Relatives

GenesActn2

GO terms

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GOName
GO:0005509 calcium ion binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005865 striated muscle thin filament
GO:0005925 focal adhesion
GO:0006936 muscle contraction
GO:0008092 cytoskeletal protein binding
GO:0019904 protein domain specific binding
GO:0030017 sarcomere
GO:0030018 Z disc
GO:0030035 microspike assembly
GO:0030175 filopodium
GO:0030274 LIM domain binding
GO:0030374 nuclear receptor coactivator activity
GO:0030674 protein-macromolecule adaptor activity
GO:0030864 cortical actin cytoskeleton
GO:0031432 titin binding
GO:0042391 regulation of membrane potential
GO:0042802 identical protein binding
GO:0043267 negative regulation of potassium ion transport
GO:0043268 positive regulation of potassium ion transport
GO:0044325 transmembrane transporter binding
GO:0045214 sarcomere organization
GO:0048041 focal adhesion assembly
GO:0051015 actin filament binding
GO:0051373 FATZ binding
GO:0051695 actin filament uncapping
GO:0055013 cardiac muscle cell development
GO:0070080 titin Z domain binding
GO:0072659 protein localization to plasma membrane
GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway
GO:0098839 postsynaptic density membrane
GO:0098978 glutamatergic synapse
GO:0099092 postsynaptic density, intracellular component
GO:1901017 negative regulation of potassium ion transmembrane transporter activity
GO:1901018 positive regulation of potassium ion transmembrane transporter activity
GO:2000009 negative regulation of protein localization to cell surface
GO:2001137 positive regulation of endocytic recycling
GO:2001259 positive regulation of cation channel activity

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001589 Actinin-type actin-binding domain, conserved siteSiteConserved site
IPR001715 Calponin homology domainDomainDomain
IPR002017 Spectrin repeatRepeatRepeat
IPR002048 EF-hand domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR014837 EF-hand, Ca insensitiveDomainDomain
IPR018159 Spectrin/alpha-actininRepeatRepeat
IPR036872 CH domain superfamilyFamilyHomologous superfamily

Diseases

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