Entity Details

Primary name ITCH
Entity type gene
Source Source Link

Details

PrimaryID83737
RefseqGeneNG_023206
SymbolITCH
Nameitchy E3 ubiquitin protein ligase
Chromosome20
Location20q11.22
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2001-04-27
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsITCH_HUMAN

GO terms

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GOName
GO:0000209 protein polyubiquitination
GO:0001558 regulation of cell growth
GO:0004842 ubiquitin-protein transferase activity
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0007219 Notch signaling pathway
GO:0016020 membrane
GO:0016567 protein ubiquitination
GO:0031410 cytoplasmic vesicle
GO:0031901 early endosome membrane
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032480 negative regulation of type I interferon production
GO:0032991 protein-containing complex
GO:0035519 protein K29-linked ubiquitination
GO:0043021 ribonucleoprotein complex binding
GO:0043066 negative regulation of apoptotic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043231 intracellular membrane-bounded organelle
GO:0044389 ubiquitin-like protein ligase binding
GO:0045087 innate immune response
GO:0045236 CXCR chemokine receptor binding
GO:0045732 positive regulation of protein catabolic process
GO:0046329 negative regulation of JNK cascade
GO:0046718 viral entry into host cell
GO:0050687 negative regulation of defense response to virus
GO:0051607 defense response to virus
GO:0051865 protein autoubiquitination
GO:0061630 ubiquitin protein ligase activity
GO:0070062 extracellular exosome
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0070534 protein K63-linked ubiquitination
GO:0070936 protein K48-linked ubiquitination
GO:0090085 regulation of protein deubiquitination
GO:1902036 regulation of hematopoietic stem cell differentiation
GO:1990763 arrestin family protein binding
GO:2000646 positive regulation of receptor catabolic process

Diseases

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Interactions

7 interactions