Entity Details

Primary name DOT1L
Entity type gene
Source Source Link

Details

PrimaryID84444
RefseqGeneNG_029793
SymbolDOT1L
NameDOT1 like histone lysine methyltransferase
Chromosome19
Location19p13.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2001-05-23
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsDOT1L_HUMAN

GO terms

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GOName
GO:0000077 DNA damage checkpoint signaling
GO:0000781 chromosome, telomeric region
GO:0003677 DNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006281 DNA repair
GO:0006348 chromatin silencing at telomere
GO:0008134 transcription factor binding
GO:0008284 positive regulation of cell population proliferation
GO:0010467 gene expression
GO:0018024 histone-lysine N-methyltransferase activity
GO:0031151 histone methyltransferase activity (H3-K79 specific)
GO:0032200 telomere organization
GO:0032991 protein-containing complex
GO:0034729 histone H3-K79 methylation
GO:0042054 histone methyltransferase activity
GO:0043231 intracellular membrane-bounded organelle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046425 regulation of receptor signaling pathway via JAK-STAT
GO:2000677 regulation of transcription regulatory region DNA binding

Diseases

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Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
DOT1LMllt3DIP23260655 details
DOT1LCbx1BioGRID, IntAct26496610 details
DOT1LScaiBioGRID, IntAct26496610 details
DOT1LEspl1BioGRID, IntAct26496610 details