Entity Details

Primary name PDE8A_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionO88502
EntryNamePDE8A_MOUSE
FullNameHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
TaxID10090
Evidenceevidence at protein level
Length823
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesPde8a

GO terms

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GOName
GO:0001934 positive regulation of protein phosphorylation
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
GO:0006198 cAMP catabolic process
GO:0007165 signal transduction
GO:0019900 kinase binding
GO:0046872 metal ion binding
GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
GO:0060548 negative regulation of cell death
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071364 cellular response to epidermal growth factor stimulus
GO:1903206 negative regulation of hydrogen peroxide-induced cell death

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000014 PAS domainDomainDomain
IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domainDomainDomain
IPR003607 HD/PDEase domainDomainDomain
IPR023088 3'5'-cyclic nucleotide phosphodiesteraseFamilyFamily
IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved siteSiteConserved site
IPR035965 PAS domain superfamilyFamilyHomologous superfamily
IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

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