Entity Details

Primary name DNM3A_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionO88508
EntryNameDNM3A_MOUSE
FullNameDNA (cytosine-5)-methyltransferase 3A
TaxID10090
Evidenceevidence at protein level
Length908
SequenceStatuscomplete
DateCreated2001-09-26
DateModified2021-06-02

Ontological Relatives

GenesDnmt3a

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000278 mitotic cell cycle
GO:0000775 chromosome, centromeric region
GO:0000791 euchromatin
GO:0000792 heterochromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001741 XY body
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003886 DNA (cytosine-5-)-methyltransferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006306 DNA methylation
GO:0006346 DNA methylation-dependent heterochromatin assembly
GO:0006349 regulation of gene expression by genetic imprinting
GO:0007283 spermatogenesis
GO:0007568 aging
GO:0008134 transcription factor binding
GO:0008168 methyltransferase activity
GO:0009636 response to toxic substance
GO:0010212 response to ionizing radiation
GO:0010216 maintenance of DNA methylation
GO:0010288 response to lead ion
GO:0010942 positive regulation of cell death
GO:0016363 nuclear matrix
GO:0030182 neuron differentiation
GO:0032355 response to estradiol
GO:0032776 DNA methylation on cytosine
GO:0033189 response to vitamin A
GO:0042220 response to cocaine
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0043045 DNA methylation involved in embryo development
GO:0043046 DNA methylation involved in gamete generation
GO:0044027 hypermethylation of CpG island
GO:0046872 metal ion binding
GO:0071230 cellular response to amino acid stimulus
GO:0071361 cellular response to ethanol
GO:0071456 cellular response to hypoxia
GO:0097284 hepatocyte apoptotic process
GO:0106363 protein-cysteine methyltransferase activity

Subcellular Location

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Subcellular Location
Chromosome
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000313 PWWP domainDomainDomain
IPR001525 C-5 cytosine methyltransferaseFamilyFamily
IPR018117 DNA methylase, C-5 cytosine-specific, active siteSiteActive site
IPR025766 ADD domainDomainDomain
IPR029063 S-adenosyl-L-methionine-dependent methyltransferaseFamilyHomologous superfamily
IPR030487 DNA (cytosine-5)-methyltransferase 3AFamilyFamily
IPR040552 DNMT3, cysteine rich ADD domainDomainDomain
IPR044108 DNA (cytosine-5)-methyltransferase 3A, ADD domainDomainDomain

Diseases

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