Entity Details

Primary name DNM3B_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionO88509
EntryNameDNM3B_MOUSE
FullNameDNA (cytosine-5)-methyltransferase 3B
TaxID10090
Evidenceevidence at protein level
Length859
SequenceStatuscomplete
DateCreated2001-09-26
DateModified2021-06-02

Ontological Relatives

GenesDnmt3b

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000775 chromosome, centromeric region
GO:0000792 heterochromatin
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0003886 DNA (cytosine-5-)-methyltransferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006306 DNA methylation
GO:0006346 DNA methylation-dependent heterochromatin assembly
GO:0006349 regulation of gene expression by genetic imprinting
GO:0008168 methyltransferase activity
GO:0010628 positive regulation of gene expression
GO:0031503 protein-containing complex localization
GO:0042826 histone deacetylase binding
GO:0043045 DNA methylation involved in embryo development
GO:0045666 positive regulation of neuron differentiation
GO:0045814 negative regulation of gene expression, epigenetic
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046872 metal ion binding
GO:0051571 positive regulation of histone H3-K4 methylation
GO:0051573 negative regulation of histone H3-K9 methylation
GO:0051718 DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
GO:0060821 inactivation of X chromosome by DNA methylation
GO:0071230 cellular response to amino acid stimulus
GO:0090116 C-5 methylation of cytosine

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000313 PWWP domainDomainDomain
IPR001525 C-5 cytosine methyltransferaseFamilyFamily
IPR011011 Zinc finger, FYVE/PHD-typeFamilyHomologous superfamily
IPR018117 DNA methylase, C-5 cytosine-specific, active siteSiteActive site
IPR025766 ADD domainDomainDomain
IPR029063 S-adenosyl-L-methionine-dependent methyltransferaseFamilyHomologous superfamily
IPR030488 DNA (cytosine-5)-methyltransferase 3B, ADD domainDomainDomain
IPR040552 DNMT3, cysteine rich ADD domainDomainDomain

Diseases

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