Entity Details

Primary name IRS2
Entity type gene
Source Source Link

Details

PrimaryID8660
RefseqGeneNG_008154
SymbolIRS2
Nameinsulin receptor substrate 2
Chromosome13
Location13q34
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-11-25
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsIRS2_HUMAN

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002903 negative regulation of B cell apoptotic process
GO:0005158 insulin receptor binding
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006006 glucose metabolic process
GO:0007165 signal transduction
GO:0007411 axon guidance
GO:0007420 brain development
GO:0008284 positive regulation of cell population proliferation
GO:0008286 insulin receptor signaling pathway
GO:0009749 response to glucose
GO:0010748 negative regulation of long-chain fatty acid import across plasma membrane
GO:0010907 positive regulation of glucose metabolic process
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0019216 regulation of lipid metabolic process
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0019904 protein domain specific binding
GO:0030335 positive regulation of cell migration
GO:0030879 mammary gland development
GO:0030890 positive regulation of B cell proliferation
GO:0032000 positive regulation of fatty acid beta-oxidation
GO:0032024 positive regulation of insulin secretion
GO:0032869 cellular response to insulin stimulus
GO:0032991 protein-containing complex
GO:0033673 negative regulation of kinase activity
GO:0038111 interleukin-7-mediated signaling pathway
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0046326 positive regulation of glucose import
GO:0046579 positive regulation of Ras protein signal transduction
GO:0048015 phosphatidylinositol-mediated signaling
GO:0051897 positive regulation of protein kinase B signaling
GO:0055088 lipid homeostasis
GO:0071333 cellular response to glucose stimulus
GO:0071889 14-3-3 protein binding

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
IRS2Sirt1BioGRID17901049 details
IRS2Xpo1IntAct26673895 details