Entity Details

Primary name NEMO_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionO88522
EntryNameNEMO_MOUSE
FullNameNF-kappa-B essential modulator
TaxID10090
Evidenceevidence at protein level
Length412
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesIkbkg

GO terms

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GOName
GO:0000151 ubiquitin ligase complex
GO:0000922 spindle pole
GO:0001782 B cell homeostasis
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006974 cellular response to DNA damage stimulus
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0008385 IkappaB kinase complex
GO:0010628 positive regulation of gene expression
GO:0016239 positive regulation of macroautophagy
GO:0019904 protein domain specific binding
GO:0031625 ubiquitin protein ligase binding
GO:0032991 protein-containing complex
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042975 peroxisome proliferator activated receptor binding
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043276 anoikis
GO:0044877 protein-containing complex binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051650 establishment of vesicle localization
GO:0065003 protein-containing complex assembly
GO:0070530 K63-linked polyubiquitin modification-dependent protein binding
GO:0072686 mitotic spindle
GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1990450 linear polyubiquitin binding
GO:1990459 transferrin receptor binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR021063 NF-kappa-B essential modulator NEMO, N-terminalDomainDomain
IPR032419 NF-kappa-B essential modulator NEMO, CC2-LZ domainDomainDomain
IPR034735 NEMO, Zinc fingerDomainDomain

Diseases

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Interactions

49 interactions

InteractorPartnerSourcesPublicationsLink
NEMO_MOUSEUBB_MOUSEDIP, MINT19766637 20404153 details
NEMO_MOUSEUBC_MOUSEBioGRID, DIP, MINT19766637 20404153 28190767 details
NEMO_MOUSERS27A_MOUSEDIP, MINT19766637 20404153 details
NEMO_MOUSERL40_MOUSEDIP, MINT19766637 20404153 details
NEMO_MOUSEIKKB_MOUSEBioGRID, DIP, IntAct, MINT, UniProt10748240 12808104 16306937 16378096 18216269 18266467 20211142 20404153 21606193 23825957 23871670 24240172 24270572 details
NEMO_MOUSERNF31_MOUSEBioGRID, MINT19136968 21455181 21811235 24469399 details
NEMO_MOUSEIKBA_HUMANBioGRID, MINT16378096 24270572 details
NEMO_MOUSERNF31_HUMANBioGRID, MINT24469399 details
NEMO_MOUSETRAF6_MOUSEBioGRID, DIP18216269 19136968 21566132 26474655 details
NEMO_MOUSENEMO_MOUSEBioGRID, DIP, IntAct18216269 19830703 20211142 24240172 details
NEMO_MOUSEMAML1_MOUSEBioGRID, IntAct20211142 details
NEMO_MOUSENFE2_MOUSEBioGRID, IntAct20211142 details
NEMO_MOUSETFE2_MOUSEBioGRID, IntAct20211142 details
NEMO_MOUSETNAP3_MOUSEBioGRID, IntAct20211142 24859449 31585000 details
NEMO_MOUSETS101_MOUSEBioGRID, IntAct20211142 details
NEMO_MOUSEIKBZ_MOUSEBioGRID, IntAct20211142 details
NEMO_MOUSECIKS_HUMANBioGRID10962033 details
NEMO_MOUSETNIP1_HUMANBioGRID16684768 details
NEMO_MOUSEHOIL1_MOUSEBioGRID19136968 details
NEMO_MOUSEIKBA_MOUSEBioGRID10748240 11009421 17158449 19091594 23951545 details
NEMO_MOUSEIKBB_MOUSEBioGRID16260493 16301747 details
NEMO_MOUSERHBD3_MOUSEBioGRID24859449 details
NEMO_MOUSEHS71B_MOUSEBioGRID, MINT16697380 19136968 details
NEMO_MOUSEIRF7_MOUSEIntAct16612387 details
NEMO_MOUSEUBC_HUMANBioGRID, MINT19763089 19766637 22819327 details
NEMO_MOUSEIKKA_MOUSEDIP, I2D, IntAct, UniProt18216269 18266467 20434986 20818435 21455181 details
NEMO_MOUSERIPK1_MOUSEBioGRID17981138 22037414 details
NEMO_MOUSEM3K7_MOUSEBioGRID19898473 21566132 details
NEMO_MOUSENKX32_MOUSEBioGRID21606193 details
NEMO_MOUSETLR4_MOUSEBioGRID19898473 details
NEMO_MOUSENLRX1_MOUSEBioGRID21703539 details
NEMO_MOUSETNR5_MOUSEBioGRID18635759 details
NEMO_MOUSETRAF2_MOUSEBioGRID18635759 23951545 details
NEMO_MOUSEUBE2N_MOUSEBioGRID18635759 details
NEMO_MOUSETNR1A_MOUSEBioGRID16547522 details
NEMO_MOUSECYLD_MOUSEBioGRID22037414 23825957 details
NEMO_MOUSEGSK3B_MOUSEBioGRID12808104 details
NEMO_MOUSESENP6_MOUSEBioGRID23825957 details
NEMO_MOUSEMAVS_MOUSEBioGRID23951545 details
NEMO_MOUSETNFA_MOUSEBioGRID24469399 29203883 details
NEMO_MOUSEGDIR1_MOUSEBioGRID24240172 details
NEMO_MOUSERHOA_MOUSEBioGRID24240172 details
NEMO_MOUSEPADI2_MOUSEBioGRID20937835 details
NEMO_MOUSESMN_MOUSEBioGRID28214532 details
NEMO_MOUSEBCL10_MOUSEBioGRID26936881 details
NEMO_MOUSETBK1_MOUSEBioGRID27776110 details
NEMO_MOUSEANGL8_MOUSEBioGRID29255244 details
NEMO_MOUSEUBS3A_HUMANBioGRID28607106 details
NEMO_MOUSETANK_MOUSEBioGRID31149635 details