Entity Details

Primary name ACVR1
Entity type gene
Source Source Link

Details

PrimaryID90
RefseqGeneNG_008004
SymbolACVR1
Nameactivin A receptor type 1
Chromosome2
Location2q24.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-07-27
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsACVR1_HUMAN

GO terms

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GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0001525 angiogenesis
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001701 in utero embryonic development
GO:0001702 gastrulation with mouth forming second
GO:0001707 mesoderm formation
GO:0001755 neural crest cell migration
GO:0002526 acute inflammatory response
GO:0003143 embryonic heart tube morphogenesis
GO:0003181 atrioventricular valve morphogenesis
GO:0003183 mitral valve morphogenesis
GO:0003203 endocardial cushion morphogenesis
GO:0003274 endocardial cushion fusion
GO:0003289 atrial septum primum morphogenesis
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0005025 transforming growth factor beta receptor activity, type I
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006468 protein phosphorylation
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007281 germ cell development
GO:0007368 determination of left/right symmetry
GO:0007507 heart development
GO:0009953 dorsal/ventral pattern formation
GO:0009968 negative regulation of signal transduction
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0016361 activin receptor activity, type I
GO:0017046 peptide hormone binding
GO:0018107 peptidyl-threonine phosphorylation
GO:0030278 regulation of ossification
GO:0030335 positive regulation of cell migration
GO:0030501 positive regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0032924 activin receptor signaling pathway
GO:0032926 negative regulation of activin receptor signaling pathway
GO:0042803 protein homodimerization activity
GO:0043235 receptor complex
GO:0045177 apical part of cell
GO:0045296 cadherin binding
GO:0045669 positive regulation of osteoblast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046332 SMAD binding
GO:0046872 metal ion binding
GO:0048179 activin receptor complex
GO:0048185 activin binding
GO:0050431 transforming growth factor beta binding
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051145 smooth muscle cell differentiation
GO:0060037 pharyngeal system development
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0060412 ventricular septum morphogenesis
GO:0060923 cardiac muscle cell fate commitment
GO:0061312 BMP signaling pathway involved in heart development
GO:0061445 endocardial cushion cell fate commitment
GO:0070724 BMP receptor complex
GO:0071363 cellular response to growth factor stimulus
GO:0071773 cellular response to BMP stimulus
GO:1905007 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
GO:1990782 protein tyrosine kinase binding
GO:2000017 positive regulation of determination of dorsal identity
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Diseases

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Interactions

41 interactions

InteractorPartnerSourcesPublicationsLink
ACVR1Ubxn1MINT15761153 details
ACVR1Fbxo30MINT15761153 details
ACVR1Nek8MINT15761153 details
ACVR1Smad6MINT23455153 details
ACVR1RhodBioGRID, MINT15761153 details
ACVR1Rab17BioGRID, MINT15761153 details
ACVR1Rhebl1BioGRID, MINT15761153 details
ACVR1Rab3bBioGRID, MINT15761153 details
ACVR1FanclBioGRID, MINT15761153 details
ACVR1Plekhb1BioGRID, MINT15761153 details
ACVR1Chn1BioGRID, MINT15761153 details
ACVR1RhojBioGRID15761153 details
ACVR1Rab33bBioGRID15761153 details
ACVR1Rras2BioGRID15761153 details
ACVR1Rps27aBioGRID15761153 details
ACVR1Sqstm1BioGRID15761153 details
ACVR1Tgfbr1BioGRID15761153 details
ACVR1PlekBioGRID15761153 details
ACVR1AjubaBioGRID15761153 details
ACVR1Fkbp4BioGRID15761153 details
ACVR1Nkiras1BioGRID15761153 details
ACVR1Rasd2BioGRID15761153 details
ACVR1Rab6bBioGRID15761153 details
ACVR1Rhobtb1BioGRID15761153 details
ACVR1Usp39BioGRID15761153 details
ACVR1Usp21BioGRID15761153 details
ACVR1Ube2e3BioGRID15761153 details
ACVR1Ube2r2BioGRID15761153 details
ACVR1Fbxo3BioGRID15761153 details
ACVR1Wdr61BioGRID15761153 details
ACVR1IkbkbBioGRID15761153 details
ACVR1Nuak2BioGRID15761153 details
ACVR1Uhmk1BioGRID15761153 details
ACVR1Cdk14BioGRID15761153 details
ACVR1Fgd6BioGRID15761153 details
ACVR1IlkapBioGRID15761153 details
ACVR1Naa20BioGRID15761153 details
ACVR1Ap2b1BioGRID15761153 details
ACVR1Stx8BioGRID15761153 details
ACVR1Rap2aBioGRID15761153 details
ACVR1Fcho1BioGRID15761153 details