Entity Details

Primary name MLH1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ9JK91
EntryNameMLH1_MOUSE
FullNameDNA mismatch repair protein Mlh1
TaxID10090
Evidenceevidence at protein level
Length760
SequenceStatuscomplete
DateCreated2001-04-27
DateModified2021-06-02

Ontological Relatives

GenesMlh1

GO terms

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GOName
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0000712 resolution of meiotic recombination intermediates
GO:0000793 condensed chromosome
GO:0000794 condensed nuclear chromosome
GO:0000795 synaptonemal complex
GO:0001673 male germ cell nucleus
GO:0002204 somatic recombination of immunoglobulin genes involved in immune response
GO:0003682 chromatin binding
GO:0003697 single-stranded DNA binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005712 chiasma
GO:0005715 late recombination nodule
GO:0006281 DNA repair
GO:0006298 mismatch repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006974 cellular response to DNA damage stimulus
GO:0007060 male meiosis chromosome segregation
GO:0007129 homologous chromosome pairing at meiosis
GO:0007131 reciprocal meiotic recombination
GO:0007140 male meiotic nuclear division
GO:0007283 spermatogenesis
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009617 response to bacterium
GO:0016321 female meiosis chromosome segregation
GO:0016446 somatic hypermutation of immunoglobulin genes
GO:0016447 somatic recombination of immunoglobulin gene segments
GO:0016887 ATP hydrolysis activity
GO:0019899 enzyme binding
GO:0032137 guanine/thymine mispair binding
GO:0032300 mismatch repair complex
GO:0032389 MutLalpha complex
GO:0032407 MutSalpha complex binding
GO:0043060 meiotic metaphase I plate congression
GO:0045132 meiotic chromosome segregation
GO:0045141 meiotic telomere clustering
GO:0045143 homologous chromosome segregation
GO:0045190 isotype switching
GO:0045950 negative regulation of mitotic recombination
GO:0048298 positive regulation of isotype switching to IgA isotypes
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0048477 oogenesis
GO:0051257 meiotic spindle midzone assembly
GO:0051321 meiotic cell cycle

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR002099 DNA mismatch repair protein family, N-terminalDomainDomain
IPR013507 DNA mismatch repair protein, S5 domain 2-likeDomainDomain
IPR014721 Ribosomal protein S5 domain 2-type fold, subgroupFamilyHomologous superfamily
IPR014762 DNA mismatch repair, conserved siteSiteConserved site
IPR020568 Ribosomal protein S5 domain 2-type foldFamilyHomologous superfamily
IPR032189 DNA mismatch repair protein Mlh1, C-terminalDomainDomain
IPR036890 Histidine kinase/HSP90-like ATPase superfamilyFamilyHomologous superfamily
IPR038973 DNA mismatch repair protein MutL/Mlh/PmsFamilyFamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
MLH1_MOUSEHFM1_MOUSEBioGRID28051769 details