Entity Details

Primary name LATS1
Entity type gene
Source Source Link

Details

PrimaryID9113
RefseqGene
SymbolLATS1
Namelarge tumor suppressor kinase 1
Chromosome6
Location6q25.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-02-18
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsLATS1_HUMAN

GO terms

Show/Hide Table
GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000287 magnesium ion binding
GO:0000819 sister chromatid segregation
GO:0000922 spindle pole
GO:0001827 inner cell mass cell fate commitment
GO:0001828 inner cell mass cellular morphogenesis
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0009755 hormone-mediated signaling pathway
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0018105 peptidyl-serine phosphorylation
GO:0019901 protein kinase binding
GO:0030216 keratinocyte differentiation
GO:0030331 estrogen receptor binding
GO:0030496 midbody
GO:0030833 regulation of actin filament polymerization
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033146 regulation of intracellular estrogen receptor signaling pathway
GO:0034613 cellular protein localization
GO:0035329 hippo signaling
GO:0035556 intracellular signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0043254 regulation of protein-containing complex assembly
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0046620 regulation of organ growth
GO:0051220 cytoplasmic sequestering of protein
GO:0051301 cell division
GO:0060644 mammary gland epithelial cell differentiation
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900181 negative regulation of protein localization to nucleus
GO:2000058 regulation of ubiquitin-dependent protein catabolic process

Diseases

Show/Hide Table

Interactions

5 interactions

InteractorPartnerSourcesPublicationsLink
LATS1Kif23BioGRID25786116 details
LATS1Nf2IntAct25026211 details
LATS1Yap1BioGRID21145499 31578200 details
LATS1Wwtr1BioGRID21145499 details
LATS1CitBioGRID30865227 details