Entity Details

Primary name NLRP12
Entity type gene
Source Source Link

Details

PrimaryID91662
RefseqGeneNG_008651
SymbolNLRP12
NameNLR family pyrin domain containing 12
Chromosome19
Location19q13.42
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2001-07-12
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsNAL12_HUMAN

GO terms

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GOName
GO:0001818 negative regulation of cytokine production
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165 signal transduction
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0009968 negative regulation of signal transduction
GO:0031953 negative regulation of protein autophosphorylation
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032661 regulation of interleukin-18 production
GO:0032692 negative regulation of interleukin-1 production
GO:0032715 negative regulation of interleukin-6 production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045345 positive regulation of MHC class I biosynthetic process
GO:0045751 negative regulation of Toll signaling pathway
GO:0050728 negative regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0071345 cellular response to cytokine stimulus
GO:1901223 negative regulation of NIK/NF-kappaB signaling
GO:1901224 positive regulation of NIK/NF-kappaB signaling

Diseases

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Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
NLRP12Hacd3IntAct25036637 details
NLRP12Usp19IntAct25036637 details
NLRP12HckI2D32226298 details