Entity Details

Primary name CNOT8
Entity type gene
Source Source Link

Details

PrimaryID9337
RefseqGene
SymbolCNOT8
NameCCR4-NOT transcription complex subunit 8
Chromosome5
Location5q33.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-11-03
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsCNOT8_HUMAN

GO terms

Show/Hide Table
GOName
GO:0000175 3'-5'-exoribonuclease activity
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0000932 P-body
GO:0003723 RNA binding
GO:0004535 poly(A)-specific ribonuclease activity
GO:0005634 nucleus
GO:0005829 cytosol
GO:0006351 transcription, DNA-templated
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0008284 positive regulation of cell population proliferation
GO:0017148 negative regulation of translation
GO:0030014 CCR4-NOT complex
GO:0030015 CCR4-NOT core complex
GO:0035195 gene silencing by miRNA
GO:0043928 exonucleolytic catabolism of deadenylated mRNA
GO:0046872 metal ion binding
GO:0061014 positive regulation of mRNA catabolic process

Diseases

Show/Hide Table

Interactions

6 interactions

InteractorPartnerSourcesPublicationsLink
CNOT8Zfp36BioGRID20595389 details
CNOT8Cnot3BioGRID, IntAct20360068 details
CNOT8Rc3h1IntAct23663784 details
CNOT8Rc3h2IntAct23663784 details
CNOT8Cnot2BioGRID, IntAct26496610 details
CNOT8Tnks1bp1BioGRID, IntAct26496610 details