Entity Details

Primary name LMX1A_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ9JKU8
EntryNameLMX1A_MOUSE
FullNameLIM homeobox transcription factor 1-alpha
TaxID10090
Evidenceevidence at transcript level
Length382
SequenceStatuscomplete
DateCreated2003-01-27
DateModified2021-06-02

Ontological Relatives

GenesLmx1a

GO terms

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GOName
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001558 regulation of cell growth
GO:0005634 nucleus
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007411 axon guidance
GO:0007417 central nervous system development
GO:0007420 brain development
GO:0007613 memory
GO:0007626 locomotory behavior
GO:0010468 regulation of gene expression
GO:0021542 dentate gyrus development
GO:0021549 cerebellum development
GO:0021766 hippocampus development
GO:0021953 central nervous system neuron differentiation
GO:0030182 neuron differentiation
GO:0030901 midbrain development
GO:0042048 olfactory behavior
GO:0045665 negative regulation of neuron differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0050808 synapse organization
GO:0071542 dopaminergic neuron differentiation
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1904948 midbrain dopaminergic neuron differentiation
GO:1905426 positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001356 Homeobox domainDomainDomain
IPR001781 Zinc finger, LIM-typeDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR017970 Homeobox, conserved siteSiteConserved site
IPR042688 Lmx1a, first LIM domainDomainDomain

Diseases

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Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
LMX1A_MOUSELDB2_MOUSEBioGRID, IntAct20211142 details
LMX1A_MOUSESSBP2_MOUSEBioGRID, IntAct20211142 details
LMX1A_MOUSEPHF10_MOUSEBioGRID, IntAct20211142 details
LMX1A_MOUSELDB1_MOUSEBioGRID, IntAct20211142 details