Entity Details

Primary name GRB14_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ9JLM9
EntryNameGRB14_MOUSE
FullNameGrowth factor receptor-bound protein 14
TaxID10090
Evidenceevidence at protein level
Length538
SequenceStatuscomplete
DateCreated2002-03-27
DateModified2021-06-02

Ontological Relatives

GenesGrb14

GO terms

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GOName
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0007165 signal transduction
GO:0008286 insulin receptor signaling pathway
GO:0010008 endosome membrane
GO:0030674 protein-macromolecule adaptor activity
GO:0030971 receptor tyrosine kinase binding
GO:0032869 cellular response to insulin stimulus
GO:0043231 intracellular membrane-bounded organelle
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0051219 phosphoprotein binding
GO:1904145 negative regulation of meiotic cell cycle process involved in oocyte maturation

Subcellular Location

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Subcellular Location
Cytoplasm
Endosome membrane

Domains

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DomainNameCategoryType
IPR000159 Ras-associating (RA) domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR015042 BPS (Between PH and SH2) domainDomainDomain
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR035034 Grb14, SH2 domainDomainDomain
IPR035035 Growth factor receptor-bound protein 14FamilyFamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily
IPR039664 GRB/APBB1IPFamilyFamily
IPR039665 APBB1IP, PH domainDomainDomain

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
GRB14_MOUSETIE2_MOUSEBioGRID10521483 details
GRB14_MOUSECNGA1_HUMANMINT20890309 details